Fertility clinics in San Francisco: Top options that match your needs

San Francisco is renowned for its medical innovation and inclusive approach to family building, but the abundance of options can make it difficult to choose the right clinic. This guide explains what to look for in a fertility clinic in San Francisco, presents some of the Bay Area IVF centers, and helps you make decisions with confidence and clarity.

What to look for in a San Francisco fertility clinic

Here’s how to check whether a clinic can provide personalized care grounded in evidence-based protocols:

There’s a lot to weigh while selecting a San Francisco fertility center that can ensure the best possible outcomes for your situation. Nucleus IVF+ can narrow down the search by matching you with clinics that align with your medical needs and values.

Book a call with the Nucleus team to get started.

Best San Francisco IVF centers and clinics

When searching for IVF treatment in San Francisco, you’ll encounter two provider types:

1. Large, full-service centers: They offer various services, numerous clinicians and specialists, in-house laboratories, and extended hours or satellite locations. These establishments can be a good fit if you need a complex, multi-stage treatment plan, value access to research and advanced technologies, or want a wide range of options under one roof.

2. Smaller, boutique-style clinics: They tend to offer a more personalized patient experience, have smaller teams, potentially more flexibility in communication, and sometimes a stronger focus on a specific niche (such as LGBTQ+ fertility treatment, fertility preservation, or donor programs). They can be a good choice if you value closer relationships, a tailored approach, and a practice that feels more patient-centered.

Source: RDNE stock project

There’s no right or wrong choice; it depends on your personal preference. To help you get started, we’ll examine three excellent yet different institutions in the Bay Area:

1. HRC Fertility

2. Spring Fertility San Francisco

3. Marin Fertility

1. HRC Fertility

With over 35 years of experience, HRC Fertility combines advanced fertility treatment with personalized protocols. Its on-site Reproductive Surgical Associates center ensures convenience as all procedures, diagnostic tests, and follow-up appointments are completed in one location.

The clinic emphasizes continuity of care, with future parents working directly with their reproductive endocrinologist from the first consultation until their OB/GYN takes over. Each treatment plan is tailored based on medical history, diagnosis, and personal goals, and the team also specializes in male factor infertility and unexplained infertility.

HRC offers a full spectrum of reproductive treatments, including:

• IVF, ICSI, and IUI

• Egg freezing

• PGT

• Single embryo transfer (SET)

• Third-party reproduction programs, including egg and sperm donation, and gestational surrogacy

• LGBTQ+ family-building solutions, with tailored solutions for gay male couples, same-sex female couples, and single parents by choice

The clinic has introduced innovative methods to make treatment more comfortable:

1. Needle-free IVF: Developed by Dr. Rachel Mandelbaum, this option involves using a small adhesive catheter instead of daily injections, enabling subcutaneous medication delivery.

2. INVOCELL treatment: A lower-cost and less invasive alternative to conventional IVF, this option allows fertilization and early embryo development to occur within a person’s body, using a patented device.

Unlike many clinics that cherry-pick candidates to maintain success statistics, HRC Fertility accepts complex cases, including parents with:

• Elevated FSH

• Poor ovarian reserve

• Compromised egg or sperm quality

Source: Anna Shvets

The clinic emphasizes patient-first care over screening-based exclusions, resulting in success stories where other clinics might have cancelled cycles. Its results are evident:

HRC Fertility doesn’t advertise its fertility treatment costs on the website, but it works with major insurance providers, including:

• Aetna

• Anthem Blue Cross

• Blue Shield of California

• Cigna

• Humana

• Carrot Fertility

• Maven Clinic

• Progyny

• WINfertility

The clinic also offers various financing options through partnerships with companies such as CapexMD and Future Family, as well as military discounts, all-inclusive egg freezing and IVF packages customized to meet each parent’s medical and financial needs.

2. Spring Fertility San Francisco

Founded in 2014 in San Francisco by physicians and scientists with backgrounds in top research hospitals, Spring Fertility has grown into one of the most recognized fertility networks in the U.S. In San Francisco, it operates these main locations:

1. Pacific Heights, which houses the primary laboratory and surgical facilities

2. SOMA, which offers a smaller, more personal environment for consultations and monitoring appointments

Besides on-site procedures and extended clinic hours, you can schedule a telehealth consultation and receive ongoing support remotely.

Spring offers full-service fertility care with a strong focus on innovation and inclusivity. The clinic offers treatment options for families of all kinds, such as gay male and female couples, trans and nonbinary parents, and single parents. Its breadth of services includes:

• Conventional, minimal stimulation, and IVF with ICSI

• Egg freezing and embryo cryopreservation

• PGT-A and PGT-M

• Donor egg and sperm programs

• Gestational surrogacy coordination

• Genetic counseling and risk assessment

• Fertility preservation for medical and elective reasons

• Mental health support, including group and individual therapy

Source: Spring Fertility

What sets Spring apart is its laboratory. Its team developed a patent-pending embryo culture system that replicates the natural environment of the human fallopian tubes and uterus, supporting embryo development.

Spring’s live birth rates per single frozen embryo transfer are:

Spring San Francisco IVF center sits at a higher end of the price spectrum in the Bay Area, but parents report decent insurance coordination and transparent financial navigation.

The clinic doesn’t publish a full price list, but it offers some estimates:

• Frozen donor egg cycle: $40,000

• Donor egg cycle with a designated donor: $60,000–$80,000

• Gestational carrier cycle: $100,000–$200,000

• Support groups and fertility wellness counseling: $300

Spring accepts fertility-specific insurance programs, such as Progyny, Carrot, Maven, and WIN, and provides dedicated Financial Navigators who help you understand your benefits, compare options, and create customized cost plans. For those paying out of pocket, the clinic partners with PatientFi for flexible payment options and Alto Pharmacy for discounted medication bundles.

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3. Marin Fertility Center (MFC)

Marin Fertility Center is a boutique-style  Bay Area IVF clinic that combines cutting-edge reproductive technology with inclusive, patient-centered care. It offers a full scope of fertility treatments, including IVF, IUI, and egg freezing, and it has in-house donor and surrogacy programs, which reduce waiting times and improve convenience.

The clinic offers innovative and alternative treatment options, including:

• Moderate IVF: Uses reduced stimulation to focus on egg quality rather than quantity, which is ideal for younger parents seeking a single child, low responders, or those sensitive to hormones.

• Intravaginal culture (IVC): Uses the INVOCELL device to facilitate embryo development within the person’s body, fostering a more intimate experience.

• In vitro maturation (IVM): Enables immature eggs to mature in the lab, offering options for parents with hormone sensitivities, certain cancers, or prior IVF failure related to egg development.

MFC offers direct access to physicians, flexible scheduling, and real-time transparency during appointments. You can view your ultrasounds live on-screen and discuss findings with your doctor, which can reduce stress and increase understanding of how the entire process unfolds.

Source: Anna Shvets

MFC has an on-site state-of-the-art laboratory, the only one of its kind in southern Marin, that offers:

• Low-energy red-light cleanroom environment to enhance egg and embryo development

• Microfluidic sperm selection for gentler preparation

• Time-lapse incubation for constant embryo monitoring

• Custom fertilization strategies (IVF, ICSI, or combined approaches)

• Carrier screening

• PGT-A, PGT-M, PGT-SR, and even whole genome sequencing and PGT-P for advanced embryo assessment

Here are Marin Fertility Center’s latest available live birth rates:

More reputable San Francisco fertility treatment options to consider

To help you compare your options and find the best fertility clinic in the Bay Area, check out several other well-known IVF centers:

With so many solid options, differing success rates, and unique approaches to care, it can be challenging to determine which IVF clinic in San Francisco is the best choice for you. You can benefit from professional guidance to help you make informed decisions in IVF care.

Nucleus IVF+ is designed to support future parents at every stage of their fertility journey, starting with selecting the clinic that can ensure the highest chance of success.

Nucleus IVF+: A new standard for IVF support

Instead of having you juggle multiple systems, services, and experts, Nucleus IVF+ integrates every step of fertility treatment into one seamless experience, combining advanced science with genuine human care to help you make data-backed decisions along the way.

Here’s what’s included:

• Clinic matching and IVF cycles: Access a vetted network of high-performing fertility clinics, matched to your medical profile and logistical preferences.

• Donor selection: Use Nucleus to find genetically compatible egg, sperm, or embryo donors (if necessary).

• Nucleus Preview: Screen for 2,000+ inherited conditions to understand your genetic background and reduce risks for your future child.

• Nucleus Embryo: Analyze, compare, and sort up to 20 embryos across nearly 1,000 genetic health, development, and well-being traits to gain insights that support embryo selection.

• Nucleus Health: Learn about your own genetic health risks and proactive care options as you grow your family.

• 24/7 genetic counseling: Access compassionate and technical guidance from genetic experts who understand both the science and the emotional side of IVF.

This integrated, data-driven approach can increase the likelihood of a healthy pregnancy by up to 20%.

Book an onboarding call to get more information.

Featured image source: Polina Tankilevitch