Orchid Health review: Is this genetic test right for you?

Orchid Health provides genetic testing for parents-to-be, helping them screen for health conditions that could affect their children. The company offers embryo DNA testing and pre-pregnancy couple carrier testing, analyzing the entire genome and screening for hundreds of common and rare health conditions and diseases.

Our Orchid Health review explains how this service works, what conditions it tests for, and how it compares to other DNA testing options on the market. It will help you decide whether this service is a good fit for your family planning.

Orchid DNA testing: An overview

Orchid Health is a biotech company based in San Francisco, California. It provides advanced whole-genome embryo screening to improve the chances of a healthy pregnancy.

Using whole-genome sequencing, Orchid offers valuable insights into parents’ health and helps make informed decisions, especially for:

• Couples undergoing IVF or those concerned about complex genetic conditions

• Patients who would typically use PGT-M can benefit from Orchid’s faster results, as it eliminates the need for probe development

• Individuals concerned about new genetic changes, such as older parents or families with a child with a non-inherited genetic condition

• Those using donor eggs, sperm, or embryos, with limited contact with the donor for testing

Orchid provides two key services, as presented in the following table:

| Service                  | Description                                                                                                                                                                                    |
| ------------------------ | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- |
| Embryo DNA testing       | Orchid uses whole-genome sequencing (WGS) to analyze embryos created through IVF and assess the risk of genetic conditions. This helps parents select the healthiest embryos for implantation. |
| Couple carrier screening | Orchid Health tests couples to see whether they carry genetic mutations linked to certain diseases. This helps identify the risk of passing on hereditary conditions

Orchid Health also offers free genetic counseling after testing to help families understand their results and make informed choices. This holistic approach to genetic health gives couples the necessary knowledge to plan their family and manage their health confidently.

How does Orchid DNA testing work?

Orchid Health whole-genome embryo reports are now available at IVF centers nationwide, making genetic testing easier to access. Here's what the process looks like:

1. Consultation: Schedule a free consultation with a board-certified genetic counselor to learn about Orchid's services. You can also ask your fertility doctor about getting access to Orchid. 

2. Sequencing process: Your IVF doctor will place an order for an Orchid DNA test. Then, an embryologist will send five cells from each embryo to Orchid's lab for complete genetic sequencing.

3. Reports: Orchid experts will analyze the genetic data and create a report on each embryo’s health risks.

4. Review with an expert: You’ll meet with a genetic counselor to discuss your results, risks, and which embryo to implant.

Carrier testing is more straightforward — here is what you need to do:

1. Take the test at home: Use Orchid's at-home kit to provide saliva samples from you and your partner.

2. Get your results: You'll receive three concise reports: a Couple Report, an Individual Report for you, and one for your partner. These reports detail your combined and individual genetic risks.

3. Talk to an expert: You can consult a genetic counselor to discuss your results and concerns.

Source: Orchid Health

Following Orchid Health's insights into your genetic risks, you can adjust your diet, fitness, and lifestyle. Additionally, follow-up embryo testing can help reduce genetic risks and ensure the best possible start for your baby.

Bonus reads — Get insights into other health-focused DNA platforms in our detailed reviews:

• Rupa Health review

• Lumen review

• Marek Health reviews

• 3x4 Genetics review

Key factors to consider

We have analyzed Orchid Health's DNA testing services, focusing on six key factors:

1. Types of insights

2. Quality and accuracy of data

3. Expert guidance 

4. Data and privacy

5. Customer reviews and satisfaction

6. Costs and pricing models

1. Types of insights

Orchid Health sets a new preimplantation genetic testing (PGT) standard with cutting-edge whole-genome sequencing. It differs from traditional PGT, which analyzes less than 1% of an embryo's genome, by using Orchid's 30x whole-genome sequencing to examine nearly 99% of an embryo's genetic code.

With this advanced screening, families can detect risks for over 1,200 monogenic conditions, including:

• Neurodevelopmental disorders: Conditions that affect brain development and function

• Congenital defects: These include heart defects, neuromuscular disorders, and vision or hearing loss

• Pediatric and hereditary cancers: Early detection can help families plan for potential health challenges

Orchid carrier screening uses a simple saliva test from both partners to check for genetic mutations that could be passed to their child. It analyzes genetic risks for chronic conditions, such as:

• Mental health conditions: Bipolar disorder, schizophrenia

• Heart disease: Atrial fibrillation, coronary artery disease

• Cancers: Breast cancer, prostate cancer

• Autoimmune & metabolic conditions: Celiac disease, type 1 and type 2 diabetes, inflammatory bowel disease

• Other health risks: Severe obesity (class III)

Source: Orchid Health

Pro tip 💡

Unlike Orchid Health, which focuses mainly on family planning, Nucleus Premium provides a broader view by screening for diseases and considers lifestyle and environmental factors to offer detailed health insights.

This enables users to address chronic conditions, prevent potential health risks, and make more informed health decisions.

The platform also offers easy-to-read reports and clear data visualizations, making complex information simple to understand. With its more affordable pricing, Nucleus provides a comprehensive and accessible health tool.

2. Quality and accuracy of results

Orchid's genetic test analyzes your entire DNA using advanced Illumina-based whole-genome sequencing technology. Its clinical-grade laboratory testing ensures that genetic markers are accurately identified in every sample. 

Orchid DNA tests were developed by top doctors and scientists and are supported by peer reviews. Top fertility clinics trust the technology, which experts in reproductive medicine and genetics continuously validate.

Source: Orchid Health 

While Orchid DNA testing is promising, some critics question the accuracy of polygenic risk scores, especially for complex conditions like mental health disorders. They argue that these scores may give parents a false sense of security by suggesting that future children will not develop certain diseases, even when genetics do not determine the outcome.

These experts also argue that using these scores across different populations can lead to inaccuracies. If the scores are applied to groups other than those used in the original studies, the results may not hold the same predictive value. As a result, many experts believe these risk scores are not yet ready for widespread use and worry that companies like Orchid may be overstating the technology's capabilities.

Some experts believe that predicting complex conditions like mental health disorders or diabetes from genetic data alone is problematic. As one Reddit user points out, you need to know a person’s health status to understand their genetic data. Without that, it’s impossible to assess an embryo's genetic risk.

[Reddit](https://www.reddit.com/r/IVF/comments/18bnuns/comment/kc6v8jg/?utm_source=share&utm_medium=web3x&utm_name=web3xcss&utm_term=1&utm_content=share_button)

3. Expert guidance

Orchid Health provides access to board-certified genetic counselors at no additional cost. After testing, you’ll receive a personalized video that explains your results in clear, simple terms.

In addition to the video, you can speak directly with a counselor. These experts are dedicated to helping both patients and clinicians interpret genetic information accurately, answering any questions or doubts you may have.

4. Data and privacy

Orchid complies with HIPAA regulations to maintain the privacy and security of protected health information (PHI). According to its privacy policy, the company implements robust security measures, including physical, managerial, and technical safeguards, to ensure data integrity.

The company uses AES-256 to encrypt stored data and transfer it over SSL, so your information is encrypted and cannot be read in case of a breach. Orchid Health also does not sell user data to third parties.

While users can request data deletion anytime, doing so will prevent access to Orchid's services. 

5. Customer reviews and satisfaction

Orchid Health's DNA test has received both praise and criticism. Many hopeful parents appreciate the peace of mind it offers despite its high price of $2,500 per embryo. 

One user shared their experience of starting IVF and feeling anxious about genetic risks. They found the process simple and were relieved when two of their three embryos tested healthy, easing their concerns. 

However, not everyone shares this positive outlook. A critic on Reddit argued that the technology is not ready for clinical use and could be risky. They also raised concerns about the test's ethical implications.

[Reddit](https://www.reddit.com/r/IVF/comments/18bnuns/comment/kc7xq3k/?utm_source=share&utm_medium=web3x&utm_name=web3xcss&utm_term=1&utm_content=share_button)

Ethical debates around embryo selection continue. While some value the ability to make informed decisions, others worry about the societal implications, including potential discrimination against individuals with certain genetic conditions.

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6. Pricing and payment options

Orchid Health's pricing for genetic testing services is not explicitly stated on its website. It mentions that Preimplantation Whole-Genome Sequencing costs around $12,500 for an IVF cycle with five biopsied embryos. These prices may vary depending on the clinic, the complexity of individual cases, and additional testing done.

Compared to tellmeGen, which offers a more budget-friendly option with its Family DNA Starter Kit, Orchid Health's pricing can be significantly higher.

Users seeking more budget-friendly options can inquire about alternative tests with limited screening parameters from Orchid Health. The cost of the Orchid Health home saliva test kit is also not listed on their website, but users can contact the company for detailed pricing information.

Verdict: Is Orchid DNA testing right for you?

Orchid Health can be helpful if you plan to have children. The company provides valuable insights into embryo health, allowing couples to reduce the risk of passing on genetic conditions. 

Orchid uses advanced technology to ensure that genetic tests are accurate. It also offers personalized recommendations that help people make informed decisions about family planning.

But the service has a few downsides. Orchid only focuses on reproductive health without considering mental well-being or lifestyle habits. Also, the service can be expensive.

Here is a summary of Orchid Health's key pros and cons:

| Pros                                                       | Cons                                                                           |
| ---------------------------------------------------------- | ------------------------------------------------------------------------------ |
| Provides detailed genetic insights for reproductive health | Only focuses on reproductive health                                            |
| Uses advanced genetic testing technology                   | Primarily targeted at couples, not individuals seeking broader health guidance |
| Offers accurate testing and easy-to-read reports           | Service may be expensive for some users                                        |
| Provides personalized reports with expert guidance         | Doesn’t give a complete picture of general health

Whole-genome sequencing offers a deeper and more comprehensive look at genetic health compared to traditional genetic tests, which analyze only a small portion of DNA. Still, considering your lifestyle and environmental factors is crucial for receiving more personalized and actionable recommendations. 

For those looking for an accessible way to leverage WGS, Nucleus Premium offers a cost-effective option with clear, easy-to-interpret reports backed by clinical-grade analysis, making advanced genetic insights accessible to everyone.

Nucleus: Transforming health information through whole-genome sequencing

Nucleus leverages the power of whole-genome sequencing to provide users with in-depth health insights. By analyzing your entire genome with 99.9% accuracy, Nucleus helps you make informed decisions about your diet, fitness, and overall health. 

Nucleus examines almost all 6 billion DNA data points while also considering lifestyle and environmental factors. This approach provides a more reliable and comprehensive overview of your health and genetic risks.

[X](https://twitter.com/trevin/status/1859450012931064098)

With a simple cheek swab, Nucleus can assess a wide range of health factors, including:

• Risk for over 800 conditions: This covers common diseases like type 2 diabetes, heart disease, and Alzheimer's, along with rare cancers and mental health conditions.

• Carrier status: It tells you whether you carry genetic variants that could be passed on to your children.

• Polygenic risk scores (PRS): These scores analyze multiple genetic factors to predict one's chances of developing certain conditions compared to others in one's ancestry group.

• Traits and dispositions: You can gain insights into your potential for longevity, muscle strength, BMI, and even intelligence.

Nucleus makes it easy to understand your results with clear reports that include graphs and simple explanations. The company also offers AI health tips, providing personalized guidance based on your results. If you need more help, you can connect with SteadyMD's board-certified genetic counselors, who partner with Nucleus.  

Nucleus processes all samples using state-of-the-art technology (Illumina's NovaSeq X Plus), one of the most advanced sequencing systems available. Their labs are CLIA-certified and CAP-accredited, ensuring top-quality results. Plus, Nucleus is HIPAA-compliant, so your data is securely protected and not shared with third parties unless you permit it.

How to get started with Nucleus

Here's how to order the Nucleus Premium kit:

1. Sign up for Nucleus Premium

2. Provide the necessary information

3. Place the order

The Nucleus Premium kit costs $399, which is covered by HSA or FSA plans. This price includes the test kit, two-way shipping, and access to all your health and trait reports. You can collect your sample at home with a painless cheek swab, and your results will be ready in about six to eight weeks. You'll get updated information on your health as the research advances without taking the test again.

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Feature image source: Gerd Altmann