3x4 Genetics review: What can this test reveal about your health?

For some people, genetic testing can be a handy way to learn about family history, but for others, it can provide valuable health insights to guide lifestyle and healthcare decisions. If you’re interested in the latter, 3x4 Genetics can offer an affordable at-home testing option regardless of your location.

With 3x4 Genetics, you can understand how your genes affect your hormones, weight management, brain health, and many other functions. The test results come with health advice to help you prevent problems and stay healthy.

Still, before investing in a test, you should learn how the service works, what to expect from it, and whether it’s worth the price. In the ensuing 3x4 Genetics review, we’ll assess these questions and many more. 

Bonus: We’ll also introduce you to Nucleus — a clinical-grade DNA platform that offers a more comprehensive genetic health assessment.

3x4 Genetics: Understand the basics

3x4 Genetics test analyzes various health markers at a single price point. Your results — or Blueprint Report — will provide insights and recommendations for six main performance areas:

1. Weight balance

2. Fitness and tissue health

3. Hormone health

4. Brain health

5. Heart health

6. Blood sugar regulation

You can order a 3x4 Genetics test kit directly from the website without requesting it through your healthcare provider. This makes the process much easier compared to its partner testing service, Rupa Health. 

Still, if you do initiate the process through a practitioner, they must have a specific 3x4 Genetics certification to order the test.

Once you receive your test kit, you collect a swab sample and mail it to the 3x4 Genetics lab, which will process it in around three to four weeks. 

Source: 3x4 Genetics

Although physician input isn’t necessary, 3x4 Genetics recommends that you consult your doctor to create a detailed action plan based on your results, medical history, and unique lifestyle habits. That said, the company can connect you with one of the practitioners from its network if needed. 

Bonus read — Get our unbiased opinions on DNA testing services similar to 3x4 Genetics:

• Myriad Genetics review

• SelfDecode review

• Invitae review

• InsideTracker review

3x4 Genetics review: A comprehensive look at 6 key elements

To determine if the 3x4 Genetics test is practical and a good fit for your needs, we’ve broken down the service into six key criteria for analysis:

1. Variety of analyses

2. Quality and accuracy of results

3. Interpretation of reports

4. Pricing and payment options

5. Data privacy and security

6. Customer experiences and reviews

1. Variety of analyses 

3x4 Genetics doesn’t allow you to choose the insights within your report. It offers one test, which analyzes various markers to provide reports for the six main performance areas: 

| Performance area          | Examples of predispositions the test screens for                                     |
| ------------------------- | ------------------------------------------------------------------------------------ |
| Weight balance            | • Appetite, satiety, and intake<br> • Adipogenesis (fat cell production)<br> • Energy expenditure |
| Fitness and tissue health | • Bone health<br> • Endurance<br> • Collagen and joints                                      |
| Hormone health            | • Hormone balance<br> • Histamine overload                                                |
| Brain health              | • Memory<br> • Mood and behavior                                                          |
| Heart health              | • Blood pressure<br> • Cholesterol<br> • Iron overload                                       |
| Blood sugar regulation    | • Glucose and insulin<br> • Hormone balance

The test looks at processes such as inflammation and methylation to provide guidelines for preventing diseases and conditions like diabetes. 

3x4 Genetics provides personalized recommendations for diet and exercise by analyzing your unique nutrigenomic needs, fitness strengths, and ideal weight. Additionally, it offers insights into how stress impacts your health and lifestyle and strategies to manage it effectively. 

2. Quality and accuracy of results 

3x4 Genetics’ lab is U.S.-based and holds the CLIA certification, which means it follows standards for accuracy, testing reliability, and results timeliness. 

A testament to the company’s commitment to quality is its foundation in over 20 years of research and the use of proprietary AI technology. Founded by Dr. Yael Joffe, a leading expert in nutrigenomics, 3x4 Genetics is backed by an advisory board of esteemed physicians and scientists.

The service analyzes around 157 genes selected based on their known connection with health-promoting actions. Notably, 3x4 Genetics doesn’t focus solely on single genes but analyzes their relationships using a systems biology framework.

Source: 3x4 Genetics

Although the 3x4 Genetics test can offer useful insights, such as your dietary needs, it can’t provide a complete picture of your genetic health profile. The company relies on limited genotyping technology and analyzes less than 1% of your DNA, so it may overlook some variants or unique genetic differences that could majorly impact your life.

Tip 💡

For a more thorough understanding of your genetic predispositions, opt for a clinical-grade test that offers whole-genome analysis. Nucleus Premium decodes nearly 100% of your genes and can provide detailed health and personal traits reports with 99.9% accuracy. 

Nucleus can reveal your predisposition to various rare and common diseases and conditions — including hereditary ones, which you may pass on to your offspring. With that knowledge, you can take ownership of your health and make more confident decisions about your lifestyle and family planning.

[X](https://x.com/melanter/status/1782094104068862183)

3. Interpretation of reports 

After analyzing your DNA, 3x4 Genetics generates a 30-page Blueprint Report designed to be easily understandable. The report achieves this by:

• Presenting the findings in a clear way

• Explaining concepts you may not know

• Including visually appealing infographics

Your results include actionable diet, supplementation, and lifestyle change recommendations. The report highlights the most critical areas that require your attention, helping you prioritize what to focus on first.

Still, some users have noted that while the test provides valuable insights, they often need additional context to interpret the results. Genetic information can be complex, and many users need more explicit guidance or expert advice to fully understand how the results apply to their specific health conditions.

Source: 3x4 Genetics

4. Pricing and payment options 

The 3x4 Genetic test costs $299 with free standard shipping. It’s also eligible for HSA and FSA payments — simply use your HSA/FSA card or pay with another card and request reimbursement later.

The company offers several payment options for your convenience, including PayPal and Klarna for installment payments.

Given its focused analysis and reports, 3x4 Genetics may not justify the price for everyone. If you're not particularly interested in nutrigenomics or weight management, alternatives like 23andMe or other services might better fit your needs.

For example, you can get the 23andMe Health and Ancestry Service for $100 less and access a much broader range of reports — over 150, to be exact. Unlike 3x4 Genetics, 23andMe also gives you access to raw data, so you can upload it to other sites and maximize your investment.

Bonus read — If you’re interested in ancestry exploration, you may find these reviews helpful:

• Ancestry.com review

• MyHeritage vs. 23andMe

• Ancestry.com alternatives

• FamilyTreeDNA review

5. Data privacy and security 

3x4 Genetics claims to abide by HIPAA and POPI standards to safeguard your sensitive data. Some of the measures it employs include:

• SSL encryption of all stored and in-transit data

• Separation of genetic and personal information

• Limited employee access to your data

• Regular reviews and updates of security practices

As for the safety of your genetic material, the company will automatically destroy your sample six months after receiving your results from the lab.

6. Customer experiences and reviews

We couldn’t find many 3x4 Genetics reviews, but most are neutral or positive. The users that liked the service found it to be informative and accurate, such as this user:

[Reddit](https://www.reddit.com/r/Biohackers/comments/182y4ln/comment/kas4x6z/?utm_source=share&utm_medium=web3x&utm_name=web3xcss&utm_term=1&utm_content=share_button)

We only encountered one negative review, which stated that the test provided generic insights that were inconsistent with the results of other tests.

3x4 Genetics is especially popular among nutrigenomics and nutrigenetics enthusiasts. It’s also commonly used by individuals with the MTHFR gene variant who want to better understand how the condition impacts their biological processes and manage it more effectively.

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The takeaways: Should you test with 3x4 Genetics?

Weigh the pros and cons of the 3x4 Genetics test to help you decide if it's the right choice for you:

| Pros                                                                                                                                                                                                                                 | Cons                                                                                       |
| ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ | ------------------------------------------------------------------------------------------ |
| • You can purchase the test directly<br> • All analyses covered with one test<br> • Simple explanations and actionable lifestyle advice<br> • Nutrigenomics insights<br> • Ability to connect with a practitioner from the network | • Limited analysis technology and insights<br> • Relatively expensive considering the scope

3x4 Genetics can be suitable for those interested in specific health areas, such as nutrition and fitness. The test can be a great starting point if you’re trying to manage your weight and receive personalized advice for healthy and effective weight loss.

Although 3x4 Genetics can reveal some genetic risks you carry, its limited scope of analysis presents a major drawback and won’t result in a complete assessment of your health. If you want to understand your DNA’s full story, choose a whole-genome test that analyzes close to your entire genome — Nucleus Premium. 

Equally affordable and straightforward, Nucleus will decode your DNA and screen for hundreds of diseases and conditions. Like with 3x4 Genetics, you’ll get actionable advice to apply to your health routine immediately.

[X](https://x.com/mndrix_/status/1781757918905307494)

Nucleus: All-in-one genetic test for a healthier tomorrow

Your genes hold abundant information, but it’s important to look at the entire genome to take full advantage of it. That way, you can get a comprehensive overview of your genetic health risks, including those related to rare diseases and conditions that can have life-altering effects. 

Nucleus Premium analyzes nearly all six billion data points of your DNA, targeting hundreds of diseases and conditions across categories such as:

• Food and diet

• Heart health

• Cancer

• Brain health

• Mental health

Besides using the latest whole-genome sequencing technology to estimate your genetic risks accurately, Nucleus accounts for non-genetic factors to provide custom absolute risk scores. Your Nucleus reports will also reveal your genes’ influence on intelligence, longevity, and muscle strength.

Like 3x4 Genetics, Nucleus provides simple explanations and illustrations that make it easy to understand your results. If you need further clarification or guidance on the next steps, Nucleus can arrange a session with a genetic counselor through SteadyMD’s network. 

One price, all insights

Nucleus Premium offers one of the most affordable whole-genome tests on the market. While similar-grade alternatives charge thousands, Nucleus is priced at just $399 and is eligible for HSA and FSA coverage.

When you purchase Nucleus Premium, you'll receive the test kit along with access to all available health and trait reports. Plus, Nucleus will keep you informed with regular report updates as the platform’s database grows, scientific understanding advances, and your risk factors evolve.

Unlock health and genetics insights with Nucleus Premium

If you're ready to test with Nucleus Premium, follow these simple steps:

1. Sign up for Nucleus Premium

2. Fill out your personal information

3. Order the kit

The testing process is simple and takes minutes — you swab your cheeks using the provided equipment and your results will be available within six to eight weeks of the lab receiving your sample.

With Nucleus, your sensitive data is always secure, as the platform is fully HIPAA-compliant. Nucleus processes samples in U.S.-based labs that are CAP and CLIA-certified, ensuring the highest standards of professionalism and accuracy.

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You can explore our other DNA testing service reviews below:

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| [Genetic Genie reviews](https://mynucleus.com/blog/genetic-genie-reviews)                  | [Dante Labs review](https://mynucleus.com/blog/dante-labs-review)                  |
| [Natera vs. Invitae](https://mynucleus.com/blog/natera-vs-invitae)                         | [Nebula Genomics review](https://mynucleus.com/blog/nebula-genomics-review)        |
| [Sequencing.com review](https://mynucleus.com/blog/sequencingcom-review)                   | [InsideTracker alternatives](https://mynucleus.com/blog/insidetracker-alternative) |
| [CRI Genetics vs. 23andMe](https://mynucleus.com/blog/cri-genetics-vs-23andme)             | [Sequencing.com vs. Nebula](https://mynucleus.com/blog/sequencingcom-vs-nebula)    |
| [Ancestry vs. 23andMe](https://mynucleus.com/blog/ancestry-vs-23andme)                     | [MyHeritage vs. Ancestry](https://mynucleus.com/blog/myheritage-vs-ancestry)       |
| [23andMe alternatives](https://mynucleus.com/blog/23andme-alternatives)                    | [tellmeGen review](https://mynucleus.com/blog/tellmegen-review)                    |
| [FamilyTreeDNA vs. 23andMe](https://mynucleus.com/blog/family-tree-dna-vs-23andme)         | [MyHeritage review](https://mynucleus.com/blog/myheritage-review)                  |
| [Illumina Sequencing vs. Sanger](https://mynucleus.com/blog/illumina-sequencing-vs-sanger) | [PacBio vs. Illumina](https://mynucleus.com/blog/pacbio-vs-illumina)               |
| [Nanopore vs. Illumina](https://mynucleus.com/blog/nanopore-vs-illumina)                   |                                                                                    |

Featured image source: Artem Podrez