the science
A deeper look into your DNA
Nucleus’ state-of-the-art testing and analysis unlock previously unavailable insights about how your DNA influences your health.
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Physician-ordered test
Physician-ordered test
troubleshoot
30x sequencing depth
30x sequencing depth
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Sequenced in the U.S.
Sequenced in the U.S.
verified_user
HIPAA compliant
HIPAA compliant
verified
CLIA certified
CLIA certified
biotech
CAP accredited
CAP accredited
our technology
A new standard in consumer DNA testing
1,000x
more DNA sequenced with Nucleus*
*compared to 23andMe, Ancestry, and similar tests
100% of your DNA
Less than 0.1% of your DNA
Less than 0.1% of your DNA
our technology
A new standard in consumer DNA testing
1,000x
more DNA sequenced with Nucleus*
*compared to 23andMe, Ancestry, and similar tests
100% of your DNA
0.1% of your DNA
0.1% of your DNA
our technology
A new standard in consumer DNA testing
1,000x
more DNA sequenced with Nucleus*
*compared to 23andMe, Ancestry, and similar tests
100%
0.1%
01 Research
Peer-reviewed research
We build upon leading private, public, and academic research to provide the most comprehensive analysis.
02 Testing
Whole-genome sequencing
Our whole-genome test is powered by Illumina's cutting-edge Novaseq X Sequencing System.
30x
Sequencing depth
30x
Sequencing depth
Quality testing
We perform 30x whole-genome sequencing to provide clinical-grade results.
Built by world-class collaborators
Our team brings decades of combined experience across genomics, computational biology, and database security. We're driven by the shared belief that we all deserve to be as informed as possible about our own health.
Lasse Folkersen, Ph.D.
Formerly lead scientist at the Danish National Genome Center and author of 100+ peer-reviewed publications
Pioneer of the largest open-source genetic analysis site
Barry Starr, Ph.D.
Formerly director of outreach at the Stanford Department of Genetics and director of science communications at Ancestry Health
Robert Plomin, Ph.D.
Professor at King’s College London and one of the most well-cited behavioral geneticists in history
Margit Burmeister, Ph.D.
Professor at the University of Michigan Medical School
Jerry Lanchbury, Ph.D.
Former Chief Scientific Officer at Myriad Genetics
Zachary G. Ives, Ph.D.
Department Chair at the University of Pennsylvania
"We intentionally designed Nucleus to deliver the highest quality clinical genetic tests, in a consumer product that's accessible to nearly everyone."
Lasse Folkersen, Ph.D.
Chief Scientific Officer
For the curious
How accurate is Nucleus?
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Nucleus’ whole-genome DNA analysis is more than 99.9% accurate. As a clinical-grade test, Nucleus is held to the highest standards to ensure the quality of your DNA analysis.
How accurate is Nucleus?
add
Nucleus’ whole-genome DNA analysis is more than 99.9% accurate. As a clinical-grade test, Nucleus is held to the highest standards to ensure the quality of your DNA analysis.
How accurate is Nucleus?
add
Nucleus’ whole-genome DNA analysis is more than 99.9% accurate. As a clinical-grade test, Nucleus is held to the highest standards to ensure the quality of your DNA analysis.
Which disease reports does Nucleus offer?
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Nucleus’ Basic and Premium plans currently offer analyses for the following diseases: ADHD The following ADHD-related genes can only be analyzed in our Premium plan: AUTS2 CRY1 FGD1 FOXP1 MBD5 MTNR1A NAA15 NF1 NRXN1 SCN1A SETBP1 SLC6A3 SLC9A9 Age-related macular degeneration (AMD) The following AMD-related genes can only be analyzed in our Premium plan: ABCA4 BEST1 C3 C1QTNF5 CDH3 CFH CFI CRB1 CRX CTNNA1 DRAM2 EFEMP1 FBLN5 HMCN1 IMPG1 IMPG2 MFSD8 PRPH2 RAX2 RDH12 RDH5 RLBP1 RP1L1 RPGR RS1 TIMP3 Alcohol dependence Alzheimer's disease The following Alzheimer’s disease-related genes can only be analyzed in our Premium plan: APP PSEN1 PSEN2 TREM2 Anxiety disorders Asthma The following asthma-related genes can only be analyzed in our Premium plan: TNFRSF13B SERPINA1 Bipolar disorder We analyze the AKAP11 gene for bipolar disorder with our Premium plan Celiac disease Chronic pain Colorectal cancer The following colorectal cancer-related genes can be only analyzed in our Premium plan: APC AXIN2 BMPR1A MLH1 MLH3 MSH2 MSH3 MSH6 MUTYH NTHL1 POLD1 POLE PTEN RNF43 SMAD4 STK11 TP53 Coronary artery disease The following coronary artery disease-related genes can be only analyzed in our Premium plan: ABCA1 ABCG5 ABCG8 APOA1 APOA5 APOB APOC2 APOC3 CREB3L3 GPIHBP1 LDLR LDLRAP1 LMF1 LPL PCSK9 Depression Endometriosis Female breast cancer The following female breast cancer-related genes can be only analyzed in our Premium plan: ATM BARD1 BRCA1 BRCA2 BRIP1 CDH1 CHEK2 CTNNA1 NBN NF1 PALB2 PTEN RAD51C RAD51D STK11 TP53 Gastric cancer The following gastric cancer-related genes can be only analyzed in our Premium plan: APC BMPR1A CDH1 CTNNA1 KIT MLH1 MSH2 MSH6 NF1 PDGFRA SDHA SDHAF2 SDHB SDHC SDHD SMAD4 STK11 TP53 Hypertension The following hypertension-related genes can be only analyzed in our Premium plan: ABCC8 ACVRL1 ATP13A3 BMPR2 CACNA1H CAV1 CLCN2 CUL3 CYP11B1 CYP11B2 CYP17A1 EIF2AK4 ENG GDF2 GGCX HSD11B2 KCNJ5 KCNK3 KDR KLHL3 NR3C2 PDE3A SCNN1A SCNN1B SCNN1G SMAD9 TBX4 TET2 WNK1 WNK4 Insomnia We analyze the CRY1 gene for insomnia with our Premium plan Male breast cancer The following male breast cancer-related genes can be only analyzed in our Premium plan: BRCA1 BRCA2 CHEK2 PALB2 Migraine The following migraine-related genes can be only analyzed in our Premium plan: ATP1A2 CACNA1A CACNA1I KCNK18 PRRT2 SCN1A SLC1A3 SLC2A1 Multiple sclerosis OCD Osteoarthritis Ovarian cancer The following ovarian cancer-related genes can be only analyzed in our Premium plan: ATM BARD1 BRCA1 BRCA2 BRIP1 MLH1 MSH2 MSH6 MUTYH PALB2 RAD51C RAD51D SMARCA4 STK11 TP53 Parkinson’s disease The following Parkinson’s disease-related genes can be only analyzed in our Premium plan: ATP13A2 ATP7B CHCHD2 DCTN1 DNAJC6 FBXO7 GCH1 LRRK2 PARK7 PDE8B PINK1 PLA2G6 PRKN PSEN1 PSEN2 RAB39B SLC6A3 SNCA SPR SYNJ1 TH VPS13C VPS35 Polycystic ovarian syndrome (PCOS) Prostate cancer The following prostate cancer-related genes can be only analyzed in our Premium plan: ATM BRCA1 BRCA2 BRIP1 CHEK2 HOXB13 MLH1 MSH2 MSH6 NBN PALB2 RAD51C RAD51D TP53 Restless legs syndrome Rheumatoid arthritis Schizophrenia The following schizophrenia-related genes can be only analyzed in our Premium plan: CACNA1G CUL1 GRIA3 GRIN2A HERC1 RB1CC1 SETD1A SP4 TRIO XPO7 Type 2 diabetes The following type 2 diabetes-related genes can be only analyzed in our Premium plan: ABCC8 CEL DNAJC3 GCK GLUD1 GPD2 HADH HNF1A HNF1B HNF4A INS KCNJ11 NEUROD1 NKX6-1 PDX1 PICK1 RFX6 WFS1
Which disease reports does Nucleus offer?
add
Nucleus’ Basic and Premium plans currently offer analyses for the following diseases: ADHD The following ADHD-related genes can only be analyzed in our Premium plan: AUTS2 CRY1 FGD1 FOXP1 MBD5 MTNR1A NAA15 NF1 NRXN1 SCN1A SETBP1 SLC6A3 SLC9A9 Age-related macular degeneration (AMD) The following AMD-related genes can only be analyzed in our Premium plan: ABCA4 BEST1 C3 C1QTNF5 CDH3 CFH CFI CRB1 CRX CTNNA1 DRAM2 EFEMP1 FBLN5 HMCN1 IMPG1 IMPG2 MFSD8 PRPH2 RAX2 RDH12 RDH5 RLBP1 RP1L1 RPGR RS1 TIMP3 Alcohol dependence Alzheimer's disease The following Alzheimer’s disease-related genes can only be analyzed in our Premium plan: APP PSEN1 PSEN2 TREM2 Anxiety disorders Asthma The following asthma-related genes can only be analyzed in our Premium plan: TNFRSF13B SERPINA1 Bipolar disorder We analyze the AKAP11 gene for bipolar disorder with our Premium plan Celiac disease Chronic pain Colorectal cancer The following colorectal cancer-related genes can be only analyzed in our Premium plan: APC AXIN2 BMPR1A MLH1 MLH3 MSH2 MSH3 MSH6 MUTYH NTHL1 POLD1 POLE PTEN RNF43 SMAD4 STK11 TP53 Coronary artery disease The following coronary artery disease-related genes can be only analyzed in our Premium plan: ABCA1 ABCG5 ABCG8 APOA1 APOA5 APOB APOC2 APOC3 CREB3L3 GPIHBP1 LDLR LDLRAP1 LMF1 LPL PCSK9 Depression Endometriosis Female breast cancer The following female breast cancer-related genes can be only analyzed in our Premium plan: ATM BARD1 BRCA1 BRCA2 BRIP1 CDH1 CHEK2 CTNNA1 NBN NF1 PALB2 PTEN RAD51C RAD51D STK11 TP53 Gastric cancer The following gastric cancer-related genes can be only analyzed in our Premium plan: APC BMPR1A CDH1 CTNNA1 KIT MLH1 MSH2 MSH6 NF1 PDGFRA SDHA SDHAF2 SDHB SDHC SDHD SMAD4 STK11 TP53 Hypertension The following hypertension-related genes can be only analyzed in our Premium plan: ABCC8 ACVRL1 ATP13A3 BMPR2 CACNA1H CAV1 CLCN2 CUL3 CYP11B1 CYP11B2 CYP17A1 EIF2AK4 ENG GDF2 GGCX HSD11B2 KCNJ5 KCNK3 KDR KLHL3 NR3C2 PDE3A SCNN1A SCNN1B SCNN1G SMAD9 TBX4 TET2 WNK1 WNK4 Insomnia We analyze the CRY1 gene for insomnia with our Premium plan Male breast cancer The following male breast cancer-related genes can be only analyzed in our Premium plan: BRCA1 BRCA2 CHEK2 PALB2 Migraine The following migraine-related genes can be only analyzed in our Premium plan: ATP1A2 CACNA1A CACNA1I KCNK18 PRRT2 SCN1A SLC1A3 SLC2A1 Multiple sclerosis OCD Osteoarthritis Ovarian cancer The following ovarian cancer-related genes can be only analyzed in our Premium plan: ATM BARD1 BRCA1 BRCA2 BRIP1 MLH1 MSH2 MSH6 MUTYH PALB2 RAD51C RAD51D SMARCA4 STK11 TP53 Parkinson’s disease The following Parkinson’s disease-related genes can be only analyzed in our Premium plan: ATP13A2 ATP7B CHCHD2 DCTN1 DNAJC6 FBXO7 GCH1 LRRK2 PARK7 PDE8B PINK1 PLA2G6 PRKN PSEN1 PSEN2 RAB39B SLC6A3 SNCA SPR SYNJ1 TH VPS13C VPS35 Polycystic ovarian syndrome (PCOS) Prostate cancer The following prostate cancer-related genes can be only analyzed in our Premium plan: ATM BRCA1 BRCA2 BRIP1 CHEK2 HOXB13 MLH1 MSH2 MSH6 NBN PALB2 RAD51C RAD51D TP53 Restless legs syndrome Rheumatoid arthritis Schizophrenia The following schizophrenia-related genes can be only analyzed in our Premium plan: CACNA1G CUL1 GRIA3 GRIN2A HERC1 RB1CC1 SETD1A SP4 TRIO XPO7 Type 2 diabetes The following type 2 diabetes-related genes can be only analyzed in our Premium plan: ABCC8 CEL DNAJC3 GCK GLUD1 GPD2 HADH HNF1A HNF1B HNF4A INS KCNJ11 NEUROD1 NKX6-1 PDX1 PICK1 RFX6 WFS1
Which disease reports does Nucleus offer?
add
Nucleus’ Basic and Premium plans currently offer analyses for the following diseases: ADHD The following ADHD-related genes can only be analyzed in our Premium plan: AUTS2 CRY1 FGD1 FOXP1 MBD5 MTNR1A NAA15 NF1 NRXN1 SCN1A SETBP1 SLC6A3 SLC9A9 Age-related macular degeneration (AMD) The following AMD-related genes can only be analyzed in our Premium plan: ABCA4 BEST1 C3 C1QTNF5 CDH3 CFH CFI CRB1 CRX CTNNA1 DRAM2 EFEMP1 FBLN5 HMCN1 IMPG1 IMPG2 MFSD8 PRPH2 RAX2 RDH12 RDH5 RLBP1 RP1L1 RPGR RS1 TIMP3 Alcohol dependence Alzheimer's disease The following Alzheimer’s disease-related genes can only be analyzed in our Premium plan: APP PSEN1 PSEN2 TREM2 Anxiety disorders Asthma The following asthma-related genes can only be analyzed in our Premium plan: TNFRSF13B SERPINA1 Bipolar disorder We analyze the AKAP11 gene for bipolar disorder with our Premium plan Celiac disease Chronic pain Colorectal cancer The following colorectal cancer-related genes can be only analyzed in our Premium plan: APC AXIN2 BMPR1A MLH1 MLH3 MSH2 MSH3 MSH6 MUTYH NTHL1 POLD1 POLE PTEN RNF43 SMAD4 STK11 TP53 Coronary artery disease The following coronary artery disease-related genes can be only analyzed in our Premium plan: ABCA1 ABCG5 ABCG8 APOA1 APOA5 APOB APOC2 APOC3 CREB3L3 GPIHBP1 LDLR LDLRAP1 LMF1 LPL PCSK9 Depression Endometriosis Female breast cancer The following female breast cancer-related genes can be only analyzed in our Premium plan: ATM BARD1 BRCA1 BRCA2 BRIP1 CDH1 CHEK2 CTNNA1 NBN NF1 PALB2 PTEN RAD51C RAD51D STK11 TP53 Gastric cancer The following gastric cancer-related genes can be only analyzed in our Premium plan: APC BMPR1A CDH1 CTNNA1 KIT MLH1 MSH2 MSH6 NF1 PDGFRA SDHA SDHAF2 SDHB SDHC SDHD SMAD4 STK11 TP53 Hypertension The following hypertension-related genes can be only analyzed in our Premium plan: ABCC8 ACVRL1 ATP13A3 BMPR2 CACNA1H CAV1 CLCN2 CUL3 CYP11B1 CYP11B2 CYP17A1 EIF2AK4 ENG GDF2 GGCX HSD11B2 KCNJ5 KCNK3 KDR KLHL3 NR3C2 PDE3A SCNN1A SCNN1B SCNN1G SMAD9 TBX4 TET2 WNK1 WNK4 Insomnia We analyze the CRY1 gene for insomnia with our Premium plan Male breast cancer The following male breast cancer-related genes can be only analyzed in our Premium plan: BRCA1 BRCA2 CHEK2 PALB2 Migraine The following migraine-related genes can be only analyzed in our Premium plan: ATP1A2 CACNA1A CACNA1I KCNK18 PRRT2 SCN1A SLC1A3 SLC2A1 Multiple sclerosis OCD Osteoarthritis Ovarian cancer The following ovarian cancer-related genes can be only analyzed in our Premium plan: ATM BARD1 BRCA1 BRCA2 BRIP1 MLH1 MSH2 MSH6 MUTYH PALB2 RAD51C RAD51D SMARCA4 STK11 TP53 Parkinson’s disease The following Parkinson’s disease-related genes can be only analyzed in our Premium plan: ATP13A2 ATP7B CHCHD2 DCTN1 DNAJC6 FBXO7 GCH1 LRRK2 PARK7 PDE8B PINK1 PLA2G6 PRKN PSEN1 PSEN2 RAB39B SLC6A3 SNCA SPR SYNJ1 TH VPS13C VPS35 Polycystic ovarian syndrome (PCOS) Prostate cancer The following prostate cancer-related genes can be only analyzed in our Premium plan: ATM BRCA1 BRCA2 BRIP1 CHEK2 HOXB13 MLH1 MSH2 MSH6 NBN PALB2 RAD51C RAD51D TP53 Restless legs syndrome Rheumatoid arthritis Schizophrenia The following schizophrenia-related genes can be only analyzed in our Premium plan: CACNA1G CUL1 GRIA3 GRIN2A HERC1 RB1CC1 SETD1A SP4 TRIO XPO7 Type 2 diabetes The following type 2 diabetes-related genes can be only analyzed in our Premium plan: ABCC8 CEL DNAJC3 GCK GLUD1 GPD2 HADH HNF1A HNF1B HNF4A INS KCNJ11 NEUROD1 NKX6-1 PDX1 PICK1 RFX6 WFS1
How does Nucleus analyze my DNA?
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Nucleus uses whole-genome sequencing to analyze your DNA for millions of variants that can impact your risk for diseases. Nucleus classifies variants into three major categories: Causal, high-effect, and common. Causal variants can single-handedly cause a disease or trait but are extremely rare. High-effect variants have a strong effect on diseases and traits — just one of them can sometimes be enough to substantially increase your chances of developing diseases or having a trait. Common variants are DNA differences more commonly found in people. One common variant alone may not significantly influence your risk of developing a specific disease or your chance of having a certain trait. But, collectively, these variants can shape your traits and influence your disease risks. The combined impact of these variants are measured through our innovative algorithms called common genetic scores (also known as polygenic scores). Through our whole-genome analysis, we are able to identify these variants and provide insights into how they affect your health and well-being.
How does Nucleus analyze my DNA?
add
Nucleus uses whole-genome sequencing to analyze your DNA for millions of variants that can impact your risk for diseases. Nucleus classifies variants into three major categories: Causal, high-effect, and common. Causal variants can single-handedly cause a disease or trait but are extremely rare. High-effect variants have a strong effect on diseases and traits — just one of them can sometimes be enough to substantially increase your chances of developing diseases or having a trait. Common variants are DNA differences more commonly found in people. One common variant alone may not significantly influence your risk of developing a specific disease or your chance of having a certain trait. But, collectively, these variants can shape your traits and influence your disease risks. The combined impact of these variants are measured through our innovative algorithms called common genetic scores (also known as polygenic scores). Through our whole-genome analysis, we are able to identify these variants and provide insights into how they affect your health and well-being.
How does Nucleus analyze my DNA?
add
Nucleus uses whole-genome sequencing to analyze your DNA for millions of variants that can impact your risk for diseases. Nucleus classifies variants into three major categories: Causal, high-effect, and common. Causal variants can single-handedly cause a disease or trait but are extremely rare. High-effect variants have a strong effect on diseases and traits — just one of them can sometimes be enough to substantially increase your chances of developing diseases or having a trait. Common variants are DNA differences more commonly found in people. One common variant alone may not significantly influence your risk of developing a specific disease or your chance of having a certain trait. But, collectively, these variants can shape your traits and influence your disease risks. The combined impact of these variants are measured through our innovative algorithms called common genetic scores (also known as polygenic scores). Through our whole-genome analysis, we are able to identify these variants and provide insights into how they affect your health and well-being.
What is whole-genome sequencing?
add
Most consumer genetic tests use a technology called microarray testing. Microarray tests look at only a tiny fraction of your DNA — less than 0.1%. This means that important health insights can be missed. In comparison, Nucleus looks at closer to 100% of your DNA — 1,000x more DNA than microarray tests — to give you a more complete picture of your health risks. Nucleus performs 30x high-depth whole-genome sequencing coverage.
What is whole-genome sequencing?
add
Most consumer genetic tests use a technology called microarray testing. Microarray tests look at only a tiny fraction of your DNA — less than 0.1%. This means that important health insights can be missed. In comparison, Nucleus looks at closer to 100% of your DNA — 1,000x more DNA than microarray tests — to give you a more complete picture of your health risks. Nucleus performs 30x high-depth whole-genome sequencing coverage.
What is whole-genome sequencing?
add
Most consumer genetic tests use a technology called microarray testing. Microarray tests look at only a tiny fraction of your DNA — less than 0.1%. This means that important health insights can be missed. In comparison, Nucleus looks at closer to 100% of your DNA — 1,000x more DNA than microarray tests — to give you a more complete picture of your health risks. Nucleus performs 30x high-depth whole-genome sequencing coverage.
Where is my DNA sample sequenced?
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Nucleus is proud to sequence your DNA 100% in the United States. Your DNA is never sent or stored overseas.
Where is my DNA sample sequenced?
add
Nucleus is proud to sequence your DNA 100% in the United States. Your DNA is never sent or stored overseas.
Where is my DNA sample sequenced?
add
Nucleus is proud to sequence your DNA 100% in the United States. Your DNA is never sent or stored overseas.
How secure and private is Nucleus?
add
Your privacy is our highest priority. In addition to being HIPAA-compliant, CLIA-certified, and CAP-accredited, we require all of our users to sign in with 2-factor authentication to ensure the security of your DNA sample, your DNA test results, and other personal data you provide to us. Your cheek DNA sample will be safely destroyed within 60 days of being received by the lab. You own your DNA data. You can download your DNA file(s) at any time. We do not share your DNA or health data with third parties, except as legally required or with your explicit consent.
How secure and private is Nucleus?
add
Your privacy is our highest priority. In addition to being HIPAA-compliant, CLIA-certified, and CAP-accredited, we require all of our users to sign in with 2-factor authentication to ensure the security of your DNA sample, your DNA test results, and other personal data you provide to us. Your cheek DNA sample will be safely destroyed within 60 days of being received by the lab. You own your DNA data. You can download your DNA file(s) at any time. We do not share your DNA or health data with third parties, except as legally required or with your explicit consent.
How secure and private is Nucleus?
add
Your privacy is our highest priority. In addition to being HIPAA-compliant, CLIA-certified, and CAP-accredited, we require all of our users to sign in with 2-factor authentication to ensure the security of your DNA sample, your DNA test results, and other personal data you provide to us. Your cheek DNA sample will be safely destroyed within 60 days of being received by the lab. You own your DNA data. You can download your DNA file(s) at any time. We do not share your DNA or health data with third parties, except as legally required or with your explicit consent.
Is Nucleus regulated?
add
Yes. Nucleus is HIPAA-compliant, CLIA-certified, and CAP-accredited. This means that we follow strict scientific guidelines and are legally required to protect your protected health information (PHI).
Is Nucleus regulated?
add
Yes. Nucleus is HIPAA-compliant, CLIA-certified, and CAP-accredited. This means that we follow strict scientific guidelines and are legally required to protect your protected health information (PHI).
Is Nucleus regulated?
add
Yes. Nucleus is HIPAA-compliant, CLIA-certified, and CAP-accredited. This means that we follow strict scientific guidelines and are legally required to protect your protected health information (PHI).
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Take the first step today
Test from the comfort of your home. No doctor’s office. No hassle.
Buy your kit
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Take the first step today
Test from the comfort of your home. No doctor’s office. No hassle.
Buy your kit
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HIPAA COMPLIANT
CLIA CERTIFIED
CAP accredited
sequenced in the u.s.
Made in the U.S.A.
@ 2024 Nucleus Genomics, Inc.
Join the movement
HIPAA
CLIA
CAP
sequenced in the u.s.
Made in the U.S.A.
@ 2024 Nucleus Genomics, Inc.
HIPAA COMPLIANT
CLIA CERTIFIED
CAP accredited
sequenced in the u.s.
Made in the U.S.A.
@ 2024 Nucleus Genomics, Inc.