MaterniT 21 PLUS by Labcorp: Things to know before taking this test

When you’re expecting, your healthcare provider may recommend prenatal tests like MaterniT21 PLUS to assess your baby’s health. This test is a part of Labcorp’s Women’s Health Panel and primarily screens for chromosomal abnormalities that could affect your baby’s development.

Several other providers offer similar prenatal screening panels, so before deciding whether to take this test, it’s essential to understand key details — including how early the test can be done, its accuracy, and the experiences of other couples who have taken it.

This article will explain everything you need to know about MaterniT21 PLUS and help you decide if it’s the right option for you.

What is the MaterniT21 test?

Labcorp’s MaterniT21 PLUS is a non-invasive prenatal test (NIPT) that checks your baby’s DNA for chromosomal abnormalities. This DNA enters your bloodstream through the placenta, which connects your baby to you in the womb.

Every human has 23 pairs of chromosomes, inherited from both parents. MaterniT21 PLUS works like most other NIPTs by checking these chromosomes for extra or missing copies. 

The MaterniT21 tests for a variety of genetic conditions, which are categorized into three main groups:

1. Trisomies: These conditions are caused by an extra copy of a chromosome.

2. Enhanced Sequencing Series (ESS): This broader panel includes additional chromosomal abnormalities.

3. Sex Chromosome Aneuploidies (SCA): These conditions involve missing or extra sex chromosomes (X or Y).

The table below outlines the specific chromosomal abnormalities included in each category:

The MaterniT21 screening can also determine your baby’s sex. However, this feature is optional, so you can opt out of receiving it until you’re ready.

How does the MaterniT21 test work?

While the MaterniT21 PLUS test can screen for a wide range of chromosomal conditions, Labcorp offers four different panel options so you and your provider can choose what’s best for your needs:

1. MaterniT21 PLUS Core

2. MaterniT21 PLUS Core + ESS 

3. MaterniT21 PLUS Core + SCA 

4. MaterniT21 PLUS Core  + ESS + SCA 

Here’s a breakdown of what each option includes:

Besides the MaterniT21 PLUS test, Labcorp offers an add-on called GENOME-Flex that allows you to:

• Check for additional chromosomal abnormalities not included in your original panel

• Use your existing blood sample, so there’s no need for another blood draw

• Receive results in about 72 hours

This option can benefit those who want a more comprehensive genetic evaluation without having to schedule extra testing appointments.

How early can you do the MaterniT21 PLUS test?

You can take any MaterniT21 PLUS panel as early as nine weeks of pregnancy. Still, some healthcare providers recommend waiting a little longer, often until 12 weeks or later. 

[Reddit](https://www.reddit.com/r/pregnant/comments/sf2lnt/comment/hun9062/?utm_source=share&utm_medium=mweb3x&utm_name=mweb3xcss&utm_term=1&utm_content=share_button)(380)

This is because the test measures fetal fraction — the small amount of your baby’s DNA that circulates in your blood. For accurate screening, at least 4% fetal fraction is needed, which is usually reached around the 10-week mark.

It’s also important to note that you can’t order this test yourself — a healthcare provider must request it for you.

Bonus — Learn about the following prenatal tests and their recommended timelines: 

• NIPT vs. amniocentesis 

• Quad screen vs. NIPT

• First-trimester screening vs. NIPT

• Cell-free DNA vs. NIPT

How long does it take to get MaterniT21 test results?

Most NIPT results take around 7–10 days to be processed. According to Labcorp, MaterniT21 PLUS results are usually available within a few business days, depending on the panel chosen:

Once your results are ready, they’ll be sent to your healthcare provider, who will usually go over them with you. If you’ve signed up for the Labcorp Patient Portal, you may also be able to view your results there.

It’s worth noting that some providers, like Myriad Genetics, don’t release NIPT results over the weekend to ensure your healthcare provider can discuss them with you. However, a few couples have reported receiving their MaterniT21 results on weekends.

That said, the actual turnaround time for MaterniT21 results can vary from person to person. While some customers received their reports in as little as five days, others had to wait nearly two weeks.

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How to interpret MaterniT21 results?

Source: Labcorp

Once your MaterniT21 PLUS test results are ready, your healthcare provider will typically review them with you. But if you get your report over the weekend or can't speak to your provider right away, here’s a quick guide to help you interpret it:

• Basic information: At the top of your report, you’ll find details about the healthcare provider who ordered your test, along with your personal information, such as your age and pregnancy details. You’ll also see the fetal fraction, the percentage of your baby’s DNA in your bloodstream.

• Test results box: Next, you’ll see a clearly labeled “Positive” or “Negative” result. Positive MaterniT21 results mean an increased risk for a chromosomal condition, while negative results suggest a lower risk. Labcorp may also provide a brief comment based on the findings.

• Results table and additional information: Below the results, you’ll find a table listing all the conditions screened for in your selected panel. This section may also include details on the test’s accuracy, methodology, and additional explanations about how the test works.

If any part of your MaterniT21 test results is still unclear, talk to your doctor — they can explain next steps or recommend follow-up testing if needed. Alternatively, Labcorp offers genetic counseling services to help you understand and navigate your results after testing.

How accurate is the MaterniT21 test?

Labcorp claims MaterniT21 PLUS is suitable for singleton pregnancies and offers select panels (PLUS Core and PLUS Core + ESS) for twin pregnancies. The company highlights that their tests have high sensitivity and specificity, which helps minimize false positives and negatives.

One unique feature about Labcorp’s MaterniT21 PLUS is that it includes the mosaicism ratio at no extra charge, which can differentiate between true and false positives by using two key data points in your results:

1. Affected fetal fraction: The proportion of a baby’s DNA fragments carrying the abnormality.

2. Total fetal fraction: The overall amount of the baby’s DNA in the sample.

The higher the mosaicism ratio, the more likely the positive result the lab provided is accurate. The lower it is, the greater the chance of a false positive report.

Despite these claims, some patients have reported inaccurate results. Common issues include:

• Tests that come back inconclusive and require a retest

• False positives that were later disproved by diagnostic tests like amniocentesis

• Difficulties in accurately screening twin pregnancies, sometimes leading to unclear or incorrect results

Here’s what one patient had to say about their experience:

[Reddit](https://www.reddit.com/r/parentsofmultiples/comments/znonqo/maternit_21_blood_test_sexes_were_wrong/?utm_source=share&utm_medium=mweb3x&utm_name=mweb3xcss&utm_term=1&utm_content=share_button)(320)

Ultimately, NIPT isn’t a diagnostic test, so false positives and negatives can happen. Many healthcare providers recommend confirmatory tests like amniocentesis when a NIPT result raises concerns.

How much is the MaterniT21 test?

One of the biggest challenges with MaterniT21 genetic testing is figuring out how much you’ll have to pay. This is because Labcorp doesn’t list prices for MaterniT21 tests on its website, making it challenging to get a precise estimate upfront.

While Labcorp does accept insurance plans, coverage varies, so you’ll need to check with your provider to confirm whether your test is included.

Several customers have complained about Labcorp’s lack of price transparency and how high their MaterniT21 bill was after testing. For instance, a customer whose insurance didn’t cover the test was charged over $1,000. However, with a MaterniT21 discount, they were able to reduce their payment to $299.

On the other hand, another customer who opted to pay without insurance was only charged $99. 

[Reddit](https://www.reddit.com/r/BabyBumps/comments/f0d1xh/comment/fgtlxri/?utm_source=share&utm_medium=mweb3x&utm_name=mweb3xcss&utm_term=1&utm_content=share_button)(340)

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MaterniT21 PLUS vs. NIPT: How does Labcorp’s test compare with other providers?

Source: Labcorp

Several providers also offer NIPT screening with panels similar to Labcorp’s test. We compared three other widely used tests to MaterniT21 PLUS:

1. Prequel Prenatal Screen by Myriad Genetics

2. Panorama by Natera

3. Sonic Healthcare’s Standard NIPT

The table below outlines the key factors we considered in our comparison:

MaterniT21 PLUS closely mirrors other NIPT providers and covers the most common chromosomal abnormalities. However, where it stands out is its faster processing time, with results often available in less than a week.

On the downside, Labcorp’s billing process isn’t the most transparent, and many patients have reported issues regarding pricing and insurance claims.

Bonus — Learn more about how the MaterniT21 PLUS vs. Natera prenatal tests differ. 

MaterniT21 PLUS: Final thoughts and recommendations 

MaterniT21 PLUS offers several features that can make it a valuable option for prenatal screening. The test’s inclusion of the mosaicism ratio is a unique advantage, and the panel options are flexible — you can choose how much information you want based on your pregnancy and risk level.

However, pricing transparency is still a major issue. Labcorp doesn’t list clear prices for the MaterniT21 tests, so it’s difficult to know how much you’d have to pay.

Despite these limitations, MaterniT21 PLUS can still provide valuable insight about your child’s health. While it can’t provide a diagnosis, it can flag potential concerns early and give you time to consider next steps.

If you’re also concerned about inherited conditions, carrier screening is often the next step. Some carrier tests, like Nucleus, screen for hundreds of conditions that might otherwise go undetected with NIPTs, like cystic fibrosis, hemophilia, and muscular dystrophy.

Nucleus uses whole-genome sequencing (WGS) to analyze nearly 100% of your DNA. This allows it to screen for hundreds of genetic conditions and give you a much more detailed understanding of your genetic risks.

Nucleus: Providing advanced carrier screening for 900+ hereditary conditions 

Nucleus offers expanded carrier screening that can test for over 900 genetic conditions. This is possible because the test uses WGS, one of the most advanced genetic testing technologies available today. 

WGS examines nearly 100% of your DNA and can detect rare genetic variants that other tests might miss. Some of the genetic conditions and illnesses the test covers include:

• Heart disease, like coronary artery disease

• Age-related macular degeneration

• Cancers like breast, prostate, and colorectal 

• Celiac disease 

• Chronic pain

Nucleus also offers a feature called partner syncing, which allows you and your partner to take the test. Once your results are in, Nucleus will analyze them to estimate your combined genetic risks. Based on these results, Nucleus AI would then recommend next steps, such as exploring different conception options.  

Beyond providing results, Nucleus also offers post-testing support through a partnership with SteadyMD. This means you’ll have access to board-certified genetic counselors who can walk you through your results and help you make informed decisions about your family’s future.

How to get started with Nucleus

The Nucleus carrier screening test is non-invasive — all it takes to collect your sample is swabbing your cheeks. It costs $499, which includes the test kit, all results, and two-way shipping. However, if you and your partner decide to take the test together and order two kits, you’ll receive a $200 discount and only pay $798 for partner testing.

You can get started by following these steps:

1. Sign up for Nucleus

2. Provide your personal details 

3. Order the test

Once you’ve sent your sample, your results will be ready in six to eight weeks. These results will provide insights into your genetic risks and guide you in making informed choices about family planning.

Understanding your carrier status is a crucial part of reproductive planning. With Nucleus, you can take this important step with ease and make informed decisions about your reproductive health even before conception.

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Featured image source: CDC