GeneDx Reviews: How reliable are their exome and genome testing services?

Genetic testing is a powerful tool for understanding inherited health risks and guiding healthcare decisions, and GeneDx is one of the many providers offering this service. They specialize in exome sequencing, which analyzes 1–2% of your DNA, and whole-genome sequencing (WGS), which provides a more comprehensive look at your genetic makeup.

According to GeneDx, their insights will help you understand how genetics influence your health and the potential risks you can pass on to your children. Still, many people are curious to know whether their services truly live up to these claims in terms of depth, accuracy, and practicality for everyday health decisions.

In this article, we'll break down all you need to know about GeneDx. We evaluate the company's services, pricing, and GeneDx reviews by users to help you get a clearer picture of what to expect. We’ll also introduce Nucleus, another provider of whole-genome testing that screens for over 800 diseases and conditions.

GeneDx: Overview of genetic testing services 

Source: GeneDx Instagram

GeneDx has been providing genetic testing for over 20 years, focusing on helping children with rare and common health conditions. Based in Stamford, UK, with a lab in Gaithersburg, they’ve screened over 14,000 infants through their genomic services. They offer three main testing options to help identify potential genetic risks:

1. Exome sequencing: Focuses on 1–2% of your DNA to identify genes that may impact health

2. Genome sequencing: Provides a more complete view of your genetic makeup by analyzing the entire genome

3. Targeted variant testing: Looks at specific genetic variants linked to known health conditions

Having sequenced over 750,000 exomes and genomes, GeneDx boasts one of the largest genomic datasets worldwide. Their lab is CLIA-certified and CAP-accredited, meaning they meet rigorous industry standards for accuracy and reliability.

While GeneDx offers extensive testing options and has a proven track record, it’s still important to carefully consider whether their services align with your needs and expectations. Understanding the technology they use and learning from past customers' experiences can help ensure you're making the right choice. 

Bonus — Explore our reviews on other providers of genetic testing services:

• Myriad Genetics review

• SelfDecode review

• Rupa Health review

• Natera vs. Invitae

Our expert GeneDx review: Vetting their services, pricing, and turnaround time

When evaluating GeneDx, we focused on six key aspects of their services:

1. Exome sequencing test

2. Genome sequencing test

3. Targeted variant test

4. Turnaround time

5. Pricing, billing, and insurance coverage

6. Service ordering process

1. Exome sequencing test

One of GeneDx’s primary services is exome sequencing, a genetic test that focuses on analyzing the protein-coding regions of your DNA. These regions, known as the exome, contain around 20,000 genes and make up about 1% of the entire genome. Despite comprising only a small portion of the genome, the exome contains most known disease-causing genetic variants.

GeneDx frequently performs exome sequencing for children with unexplained neurological or developmental conditions, such as non-traumatic epilepsy, intellectual disabilities, and congenital anomalies. They offer three exome sequencing tests:

1. XomeDx: Analyzes the exome to detect genetic variants associated with epilepsy, developmental delays, and other neurological conditions

2. XomeDxPlus: Examines your exome and mitochondrial genome, which are linked to conditions that affect energy-demanding organs such as the heart and brain. It’s typically recommended for people who are suspected to have a mitochondrial disorder like Leigh Syndrome

3. XomeDxXpress: Exome test for critically ill patients who require fast diagnosis. It has a short turnaround time as provisional results are usually out within a week

While GeneDx’s exome sequencing is designed to be comprehensive, some users have noted limitations in detecting certain genetic variants. Like many exome sequencing tests, GeneDx’s analysis may not always detect complex structural variations, which could impact its ability to provide a fully comprehensive genetic picture.

For example, one Reddit user shared that their GeneDx test did not detect a gene associated with ALS:'

[Reddit](https://www.reddit.com/r/ALS/comments/1c0b5c5/genome_testing_results_genedx_and_invitae/?rdt=47553)

2. Genome sequencing test 

GeneDx also offers whole-genome sequencing, which analyzes the genetic instructions that guide your body’s growth, metabolism, and immune response.

Unlike exome sequencing, WGS evaluates your genome's protein-coding and noncoding regions. This provides a broader picture of the genetic variants linked to diseases, genetic predisposition, and potential illness responses.

GeneDx’s genome tests are divided into two main categories:

1. GenomeSeqDx: Evaluates both the mitochondrial and nuclear genomes to detect genetic variants associated with various conditions, such as inherited cardiac disorders, cancer, and cardiomyopathy

2. GenomeXpress: Designed for critically ill patients who need an expedited turnaround time. Provisional results are typically available in five days, with final reports expected in two weeks

Although GeneDx’s WGS provides a fuller picture than exome sequencing, some users have reported limitations. For example, a Reddit user reported that GeneDx’s WGS test failed to detect certain genetic variants:

[Reddit](https://www.reddit.com/r/genetics/comments/1hil159/genedx_whole_genome_gene_list/)

Bonus tip: Considering some user-reported limitations of GeneDx’s WGS services, you might want to check out other providers that offer more comprehensive insights. One provider to consider is Nucleus, with a WGS test that screens for over 800 conditions and diseases, including cancer, hypertension, and heart disease.

The platform also offers Nucleus AI, a feature that analyzes your genetic data to provide personalized health recommendations. This tool helps break down your reports and gives tailored insights on diet, lifestyle, and supplements to guide your health decisions.

3. Targeted variant testing

Along with their WGS service, GeneDx offers a more targeted test if you're interested in analyzing a specific genetic variant known to run in your family. The test focuses on detrimental or likely detrimental variants already found in your family, making it a simpler option if you’re looking for targeted analysis.

Results are typically positive or negative, showing whether the variant is present. It can also be used for carrier testing, which helps you understand if you're at risk of passing on inherited conditions like amelogenesis imperfecta and craniocervical dystonia to your children.

One key limitation is that it only tests for the selected gene, so other potential genetic variants won’t be detected. Because of this, if you’re after a more thorough genetic analysis, it’s a good idea to consider a comprehensive test like WGS.

Bonus — Learn about the genetic testing services the following providers offer:

• 23andMe review 

• Genetic Genie review

• Invitae genetics testing review 

• MyHeritage review  

• FamilyTreeDNA vs. 23andMe 

4. Turnaround time

GeneDx’s turnaround time depends on the specific test. Here’s what the company estimates for each service:

| Test                                        | Turnaround time                                          |
|---------------------------------------------|----------------------------------------------------------|
| XomeDx                                      | 4 weeks                                                  |
| XomeDx Plus                                 | 5 weeks                                                  |
| XomeDxXpress                                | • Preliminary results in 7 days<br>• Full report in 2 weeks  |
| GenomeSeqDx                                 | 4 weeks                                                  |
| GenomeXpress                                | • Preliminary results in 5 days<br>• Final report in 2 weeks |
| Targeted variant testing (familial variant) | 3 weeks

While these estimates provide a general idea of how long testing takes, GeneDx notes that these timeframes are only approximations. The actual turnaround times may vary based on sample processing and lab capacity. 

5. Pricing, billing, and insurance coverage 

GeneDx’s billing process isn’t the most transparent. While the company claims to accept a wide range of insurance plans, including Medicaid, they don’t provide upfront cost estimates for Medicaid patients, which can lead to uncertainty about potential out-of-pocket costs.

Because genetic testing often requires prior authorization, GeneDx suggests getting approval ahead of time. Still, in most cases, they can submit the request on your behalf through their third-party vendor, Careviso.

Your final cost depends on your insurance plan and can include copays, coinsurance, and deductibles. If needed, GeneDx offers financial assistance, but you’ll need to apply after receiving your bill.

Some customers have reported unexpected charges, with one patient sharing that they were billed nearly $10,000:

[Reddit](https://www.reddit.com/r/ehlersdanlos/comments/15x79xu/genedx_rant/)

Bonus tip: If you’re looking for clearer billing, Nucleus offers a more straightforward pricing structure.

For $399, you’ll receive a test kit, two-way shipping, and personalized reports that translate complex data into practical insights for your health.

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6. Service ordering process

Source: GeneDx YouTube

GeneDx’s services are not direct-to-consumer. This means your primary healthcare provider must order the tests on your behalf. After the test is completed, the results and any relevant findings are sent directly to your provider for review.

GeneDx partners with Genomic Medical, which connects you with a genetic provider who can assess your health and, if eligible, order the appropriate test. Typically, you’ll need to explain your symptoms and health history in detail, and the provider will evaluate whether further testing is necessary.

Final thoughts on GeneDx: Key takeaways 

After thoroughly evaluating GeneDx’s services, our team found several strengths and weaknesses in their offerings. Below is a summary of our analysis:

| Pros                                                                                              | Cons                                                                          |
|---------------------------------------------------------------------------------------------------|-------------------------------------------------------------------------------|
| Comprehensive testing options:<br> exome, genome, and targeted variants                               | Certain conditions or genes can be<br>missed in their gene testing analysis      |
| Large database from over 750,000<br> exomes and genomes sequenced                                     | Delays in sample shipping to their labs<br>can result in longer turnaround times |
| Genome Medical partnership can<br> assist in ordering tests for patients<br> without healthcare providers | Lack of pricing transparency, which<br>often leads to high surprise bills        |
| Financial assistance for eligible<br> patients to reduce out-of-pocket costs                          | &nbsp;                                                                        |
| Expedited results can be obtained<br>

GeneDx offers a variety of genetic tests, and in some cases, you can even get expedited results. But one of its biggest drawbacks is the lack of pricing transparency — patients have reported receiving surprise bills they didn’t see coming. There have also been reports of their tests missing certain genetic variants, which can be frustrating if you're relying on the results for important health decisions.

If you want a more straightforward and comprehensive option, Nucleus Premium offers a whole-genome sequencing test that analyzes nearly 100% of your DNA for $399 — no hidden fees, no guesswork. With Nucleus, you get a deeper look into your genetic health, including risks for conditions like heart disease and cancer — so you can take action with confidence.

Nucleus: Unlock insights from your DNA to guide your health

Nucleus uses whole-genome sequencing to analyze six billion DNA data points. It estimates your risk for over 800 diseases and conditions like heart disease, cancer risks, and more. It’s a complete look at your genetic makeup — much more than what typical genetic tests offer.

For $399, you’ll get everything you need — a test kit, prepaid two-way shipping, and simple, easy-to-understand reports. These reports will give you clear insights to help you manage your health risks without any confusing medical jargon.

To provide a more comprehensive picture of your health, Nucleus takes into account not only your genetic data but also lifestyle factors like:

• Age

• Cholesterol levels

• BMI

• Blood pressure

• Smoking status

The results are processed using cutting-edge equipment here in the U.S. Nucleus is HIPAA-complaint, and all testing is done in CLIA-certified and CAP-accredited labs, so you can trust that they meet the highest standards for reliability.

Ordering Nucleus’ testing kit

To order the test kit and begin your journey to better health, follow these easy steps:

1. Sign up for Nucleus Premium

2. Provide your personal information

3. Order your kit

Once your kit arrives, use the cheek swab to collect a sample as instructed and send it back with the prepaid label. After six to eight weeks, you’ll receive a detailed report about your genetic makeup and health risks.

Get actionable insights about your health. Order your test kit today! 

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Featured image source: Paul Danilyuk