TruDiagnostic review: Learn all about its epigenetic tests, accuracy, and pricing

Your lifestyle doesn’t just shape how you feel. It influences how you age at a cellular level. Epigenetic tests, such as those offered by TruDiagnostic, aim to reveal your biological age, helping you see whether your habits are accelerating or slowing down your aging process.

But is epigenetic testing truly valuable? Many people question whether the technology is advanced enough to provide meaningful insights or if it’s just an expensive wellness trend.

TruDiagnostic continues to collaborate with experts from top academic institutions to offer a science-backed approach. Their tests analyze key biomarkers that influence overall health, such as antioxidants, inflammation, and oxidative stress. Still, before spending hundreds of dollars, it's important to take a closer look at what these tests actually provide.

This TruDiagnostic review breaks down their epigenetic testing services, accuracy, and pricing. We’ll also introduce Nucleus, a genetic testing platform that goes beyond epigenetics by analyzing your entire genome and factoring in lifestyle influences.

What is TruDiagnostic?

Source: TruDiagnostic

Since 2020, TruDiagnostic has been developing one of the largest private DNA methylation databases, using it to examine how lifestyle factors influence aging at a cellular level. Unlike traditional genetic tests that focus on fixed traits, TruDiagnostic measures biological aging by tracking changes in gene expression over time.

The company offers three tests:

• TruAge

• TruHealth

• TruAge + TruHealth

These tests evaluate how environmental factors and personal choices, such as smoking status, stress, and diet, influence your health, including:

• Biological age

• Speed of aging

• Organ health

Each test analyzes a specific number of biomarkers and incorporates advanced aging algorithms, including Symphony Age Score, OMICm Age, and Dunedin Pace Score. TruDiagnostic’s laboratory is CLIA-certified, and the company collaborates with Harvard, Yale, Duke, and Columbia to refine their technology. 

Based on their analysis, users receive a detailed report comparing their chronological and biological age. The reports include insights into how lifestyle factors — like diet, stress, and smoking — can impact their health. 

TruDiagnostic recommends retesting with their kits every three months to track how changes to your environment and habits affect your overall health.

Bonus — If you're interested in other providers of health-related testing services, check out these reviews:

• InsideTracker review

• Dante Labs review

• Invitae genetics testing review

• 3x4 Genetics review

How does TruDiagnostic work?

TruDiagnostic provides an at-home test kit that you can order straight from their website. The sample collection process involves a few straightforward steps.

Unlike some DNA tests that rely on saliva, TruDiagnostic exclusively uses blood samples. Users collect the sample at home using one of two methods:

1. Finger-prick test: Users prick a finger with a small lancet and deposit a few drops of blood onto a provided blood spot card

2. Tasso device: This automated device attaches to the arm and draws a small blood sample

After collecting the sample, you'll mail it back to TruDiagnostic’s lab. Once processed, you’ll receive a report detailing your biological age, aging pace, and health markers, plus personalized recommendations to improve health and potentially reduce biological age.

Five crucial factors we considered for our TruDiagnostic review

When we evaluated TruDiagnostic’s services, we focused on five key criteria:

1. Tests offered 

2. Accuracy

3. Reports provided

4. Pricing

5. Turnaround time

1. Tests offered 

Source: TruDiagnostic

TruDiagnostic offers three epigenetic tests, each analyzing a different number of biomarkers to assess how lifestyle and environmental factors influence health.

Here’s a breakdown of the tests:

• TruAge: Assesses 75+ biomarkers to estimate biological age, track aging speed, and evaluate key organs like the heart, liver, and kidneys

• TruHealth: Analyzes 110+ biomarkers related to brain function, immune response, and metabolism, including oxidative stress and inflammation

• TruAge + TruHealth: Combines both tests, evaluating 185 biomarkers for a more detailed look at aging, metabolic function, and overall health 

TruDiagnostic promotes its tests as being backed by one of the largest private DNA methylation databases and developed with input from aging research experts. However, many still remain skeptical about the reliability and usefulness of epigenetic testing: 

[Reddit](https://www.reddit.com/r/PeterAttia/comments/134o73v/comment/jin9lli/?utm_source=share&utm_medium=mweb3x&utm_name=mweb3xcss&utm_term=1&utm_content=share_button)

💡Tip 

Epigenetic tests focus on how lifestyle influences gene expression but don’t account for inherited genetic risks. In contrast, most genetic tests identify DNA variants but ignore how daily habits impact health over time.

For a more complete picture, Nucleus integrates whole-genome sequencing (WGS) with lifestyle data to generate reports on both inherited risks and lifestyle-driven changes — helping you make informed health choices.

2. Accuracy

TruDiagnostic’s tests estimate your biological age by looking at DNA methylation patterns. As we age, these patterns change, which is why they’re used when estimating how quickly we're aging. TruDiagnostic’s tests focus on certain DNA regions called CpG sites, which are especially important for measuring biological age.

Despite the science behind TruDiagnostic, some users have questioned the accuracy of its tests. One reviewer in particular has raised concerns about the reliability of results due to the method of sample collection:

[Reddit](https://www.reddit.com/r/blueprint_/comments/198f17z/comment/ki77arr/?utm_source=share&utm_medium=mweb3x&utm_name=mweb3xcss&utm_term=1&utm_content=share_button)

Dried blood spot testing does have its limitations. Factors like sampling bias due to blood composition can affect the consistency of measurements, and without clear reference ranges, it can be harder to interpret the results.

3. Reports provided

Source: TruDiagnostic

Based on your results, TruDiagnostic provides reports on your body's aging process and the lifestyle factors that can affect your long-term health. The results will typically include:

• OMICm age report: Estimates biological age and assesses risks for conditions like stroke, cancer, heart disease, COPD, depression, and Type II diabetes

• Fitness report:  Evaluates key fitness-related markers such as walking speed, muscle strength, and lung function

• Immune report: Analyzes immune system health by measuring immune cell concentrations and ratios

• Pace of aging: Uses the DunedinPACE algorithm to assess how quickly your body is aging at a given moment

• Weight loss response: Predicts how your metabolism may respond to dietary changes

• Smoke and alcohol exposure reports: Measure how past or ongoing exposure to smoking and alcohol may be impacting your health and aging trajectory

While these reports offer valuable insights, some users find them difficult to interpret without expert help. TruDiagnostic does provide expert consultations to help users better understand their results, but these come at an additional cost. Given the high cost of the test itself, many users feel frustrated by the added expense for a complete breakdown of their data:

[Reddit](https://www.reddit.com/r/blueprint_/comments/19cog78/comment/kj0z1nc/?utm_source=share&utm_medium=mweb3x&utm_name=mweb3xcss&utm_term=1&utm_content=share_button)

4. Pricing

TruDiagnostic’s pricing is based on the test selected and whether you choose a one-time purchase or a subscription for ongoing tracking. Below is a breakdown of the costs for each option:

| Test               | Single test cost | Subscription plan (Yearly) |
|--------------------|-----------------|---------------------------|
| TruAge            | $499             | $998                      |
| TruHealth         | $499             | $998                      |
| TruAge + TruHealth | $849             | $1,998

TruDiagnostic’s tests aren’t covered by insurance, so you’ll need to pay entirely out of pocket. However, they do accept HSA and FSA payments, making it easier to use pre-tax dollars to cover some of the cost.

[CTA]({
  "title":"Get 10% off your whole-genome kit",
  "cta":{
    "label":"Order your kit",
    "href":"https://www.mynucleus.com/product?promocode=welcome10"
  }
})

5. Turnaround time

TruDiagnostic estimates a two- to three-week  turnaround time for test results after receiving your sample. 

Once you submit your sample, you can track its progress through different stages. The status will first show when the sample is received, and then updates are provided as it moves through processing and analysis.

Still, some users have reported inconsistencies in the updates, with samples sometimes seeming to reach the final stages only to be sent back for reprocessing unexpectedly: 

[Reddit](https://www.reddit.com/r/blueprint_/comments/1icxkum/trudiagnostic/?utm_source=share&utm_medium=web3x&utm_name=web3xcss&utm_term=1&utm_content=share_button)

These inconsistencies have caused frustration for some users, with many questioning the transparency and reliability of the testing process. While there may be valid technical reasons behind the delays — such as batch processing and occasional quality control issues — TruDiagnostic has not effectively communicated these reasons, leaving some users uncertain about the status of their tests. 

Final verdict on TruDiagnostic reviews: Are their services right for you?

While TruDiagnostic’s epigenetic testing offers valuable insights, it also has limitations. Here’s a look at the main pros and cons based on customer feedback and expert analysis:

| Pros                                                                                                             | Cons                                                                                   |
| ---------------------------------------------------------------------------------------------------------------- | -------------------------------------------------------------------------------------- |
| Uses one of the largest private DNA<br>methylation databases in the world                                           | Some users report long turnaround<br>times                                                |
| Offers multiple epigenetic tests                                                                                 | Results can be difficult to understand<br>without expert guidance (additional fees<br>apply) |
| Measures 70–185+ biomarkers,<br>depending on the test                                                               | Tests aren’t covered by insurance,<br>so you’ll pay out-of-pocket                         |
| Research and testing methods<br>developed in collaboration with leading<br>academic institutions like Harvard and<br>Yale | Scope of testing limited to lifestyle<br>

While TruDiagnostic’s tests focus on epigenetics, they don’t address the role of inherited genetic risks. Epigenetic insights can be valuable for understanding how habits and environment shape your health, but they don’t give you the whole picture. Genetic testing, on the other hand, looks at your inherited DNA to identify risks for specific conditions.

To get a fuller picture of your health, it’s important to look at both: 

1. The influence of your environment and habits on gene expression 

2. The inherited genetic factors that affect your health

Nucleus provides this comprehensive view by sequencing ~100% of your genome. Through whole-genome sequencing, it analyzes inherited health risks while also factoring in lifestyle influences, giving you a clearer and more actionable understanding of your health.

Nucleus’ WGS test: A smart way to take control of your health

Most genetic tests analyze only a small selection of genes, but Nucleus takes a more holistic approach. By sequencing nearly your entire genome, it examines six billion DNA data points, offering a much deeper look at your genetic health risks.

For $399, Nucleus gives you an in-depth breakdown of your genetic predisposition to over 800 diseases and conditions, including:

1. ADHD

2. Hypertension 

3. Cancer

4. Heart disease

5. Parkinson’s disease

6. Depression

7. Chronic pain

8. Migraine

9. PCOS

Beyond genetic testing, Nucleus also considers key lifestyle factors — like age, BMI, blood pressure, and metabolic health — to give you a personalized health risk profile.

To make it even more practical, Nucleus AI combines your genetic and lifestyle data to generate tailored recommendations for diet, supplements, lifestyle changes, and healthcare — all backed by science and customized to your unique genetic makeup.

Get started with Nucleus’ all-in-one-test

Taking the first step toward better health with Nucleus is easy. Follow these steps to begin your journey:

1. Sign up for Nucleus Premium

2. Provide your personal information

3. Order your test kit, which will be shipped directly to your doorstep

After shipping your sample, you’ll receive your detailed and easy-to-understand health report in six to eight weeks, highlighting your genetic predispositions and lifestyle-based health factors.

Take charge of your health today and unlock the power of your DNA. Order your Nucleus test kit today!

You may also like…

|                                                                              |                                                                                                       |
|------------------------------------------------------------------------------|-------------------------------------------------------------------------------------------------------|
| [Genetic Genie review](https://mynucleus.com/blog/genetic-genie-reviews)     | [FamilyTreeDNA vs. 23andMe](https://mynucleus.com/blog/family-tree-dna-vs-23andme)                    |
| [InsideTracker alternative](https://mynucleus.com/blog/insidetracker-review) | [CRI genetics vs. 23andMe](https://mynucleus.com/blog/cri-genetics-vs-23andme)                        |
| [PacBio vs. Illumina](https://mynucleus.com/blog/pacbio-vs-illumina)         | [Ancestry vs. 23andMe review](https://mynucleus.com/blog/ancestry-vs-23andme)                         |
| [MyHeritage review](https://mynucleus.com/blog/myheritage-review)            | [MyHeritage vs. Ancestry review](https://mynucleus.com/blog/myheritage-vs-ancestry)                   |
| [Myriad Genetics review](https://mynucleus.com/blog/myriad-genetics-review)  | [SelfDecode review](https://mynucleus.com/blog/selfdecode-review)                                     |
| [MyHeritage vs. 23andMe](https://mynucleus.com/blog/myheritage-vs-23andme)   | [Ancestry alternatives](https://mynucleus.com/blog/ancestrycom-alternatives)                          |
| [Ancestry review](https://mynucleus.com/blog/ancestrycom-review)             | [23andMe alternatives](https://mynucleus.com/blog/23andme-alternatives)                               |
| [Sequencing review](https://mynucleus.com/blog/sequencingcom-review)         | [Sequencing vs. Nebula Genomics](https://mynucleus.com/blog/sequencingcom-vs-nebula)                  |
| [Rupa Health review](https://mynucleus.com/blog/rupa-health-review)          | [Natera vs. Invitae](https://mynucleus.com/blog/natera-vs-invitae)                                    |
| [23andMe review](https://mynucleus.com/blog/23andme-review)                  | [Illumina sequencing vs. Sanger sequencing](https://mynucleus.com/blog/illumina-sequencing-vs-sanger) |
| [FamilyTreeDNA review](https://mynucleus.com/blog/familytreedna-reviews)     |                                                                                                       |

Featured image source: Paul Danilyuk