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Clinics

Research

Laboratorios

Centro de Optimización Genética

El centro para la comunidad científica y clínica para validar, construir y evaluar modelos ponderados abiertos.

Featured models

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Origin

2025

Nucleus Origin is a set of open-weighted prediction models for nine different diseases. It has been trained and validated on 1.5 million people across diverse ancestries.

Open-weights

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White Paper

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Origin

2025

Nucleus Origin is a set of open-weighted prediction models for nine different diseases. It has been trained and validated on 1.5 million people across diverse ancestries.

Open-weights

download

White Paper

developer_guide

Learn more

Thompson

2024

Genomics plc paper presented a flagship set of PRS developed and validated across multiple biobanks.

Mars

2022

Researchers at the University of Helsinki and the Broad validated PRS in the FinnGen biobank, showing large improvements over previous work.

Benchmarks

Liability R² by disease

Origin

Thompson

Mars

Liability R2

0.3

0.2

0.1

Alzheimer's disease

Breast cancer

CAD

Endometriosis

Hypertension

Prostate cancer

Rheumatoid arthritis

Type 1 diabetes

Type 2 diabetes

Liability R² by Disease and Ancestry

African

Admixed American

East Asian

South Asian

Liability R2

0.3

0.2

0.1

Breast cancer

CAD

Endometriosis

Hypertension

Prostate cancer

Rheumatoid arthritis

Type 2 diabetes

See risk reductions for

Alzheimers risk can be reduced by up to 55.3% when selecting from 5 embryos.

Estimated risk (%)

55.3% risk
reduction

0

0

2

5

10

Random
embryo

# of embryos to select from

Request Origin model weights

All researchers are invited to evaluate, build upon, and get access to Origin.

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open_in_new

Request Origin model weights

All researchers are invited to evaluate, build upon, and get access to Origin.

Request

open_in_new

References

Mars N, Lindbohm JV, Della Briotta Parolo P, et al. Systematic comparison of family history and polygenic risk across 24 common diseases. Am J Hum Genet. 2022 Dec 1;109(12):2152-2162. doi: 10.1016/j.ajhg.2022.10.009. Epub 2022 Nov 7. PMID: 36347255.

Thompson DJ, Wells D, Selzam S, et al. A systematic evaluation of the performance and properties of the UK Biobank Polygenic Risk Score (PRS) Release. PLoS One. 2024 Sep 18;19(9):e0307270. doi: 10.1371/journal.pone.0307270. PMID: 39292644.

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