Liposomal NAD benefits: Is this NAD delivery method effective and safe?

Nicotinamide adenine dinucleotide (NAD) has garnered plenty of attention in the biohacking community in recent years. This molecule occurs naturally in our cells, helps them generate energy, and adapt to bioenergetic stress. Recent studies indicate that supplementing NAD could have numerous benefits on the user’s health and longevity. 

There are many ways to increase NAD, but we need more research to determine the optimal administration methods, schedules, and doses. Still, when it comes to oral supplementation, the liposomal form of NAD may be superior to other nicotinamide adenine dinucleotide forms.

To bring some clarity to this topic, we’ll discuss liposomal NAD’s benefits and the science behind them. You’ll also learn about the positive effects of NAD supplements, potential drawbacks, and precautions you need to take before using them.

Disclaimer: The information in this article shouldn’t be taken as medical advice. Consult your healthcare provider before taking any supplement to reduce the chance of adverse reactions. 

What is liposomal NAD?

Liposomal NAD products are oral supplements designed to transport NAD molecules through plasma via liposomes, artificial vesicles with a double lipid layer. These layers are hydrophobic, meaning they repel water and encapsulate water-soluble substances, such as NAD precursors. 

Liposomes are often used to carry active compounds in cosmetic and pharmaceutical products. They are also common in the food industry as carriers of flavors and antimicrobials.

As our bodies can’t absorb NAD efficiently, the liposomal method is primarily used to deliver NAD precursors. Nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) are the two most researched options, and their efficacy in increasing NAD levels has been established. Other forms of NAD boosters, like nicotinamide (NAM), nicotinic acid (NA), and tryptophan, might not be as effective.

Enclosed in the lipid layers, the NAD precursor is protected from the body’s aqueous environment. The protective layer deteriorates over time or fuses with the cells’ membranes, allowing the liposomes to release the inner content.

Source: HeungSoon

Is liposomal NAD better than other delivery methods? 

There is still insufficient scientific evidence confirming that liposomal NAD is more effective than other forms of NAD. That said, liposomal delivery is generally thought to have many advantages over other methods, mainly:

• High bioavailability: The liposomal method mimics the body’s natural transport system. Also, liposomes protect the substance from being broken down in the stomach, increasing its absorption and stability.

• Improved safety: Liposomes are generally well-tolerated and exhibit low toxicity and immunogenicity, so the likelihood of a negative reaction is relatively low.

• Controlled delivery: This delivery method may help ensure that the drug is released at the right time, in the right amount, and in the right place, increasing its efficacy.

• Extended half-life: With liposomal delivery, the drug may remain in the bloodstream for longer, enabling sustained effects.

• Easier production: Liposomes can be produced on a large scale, and their properties can be adjusted for different applications.

Liposomal NAD may also have a longer shelf-life than other forms, though this depends on many factors, including the specific formulation and storage conditions.

Source: Chokniti Khongchum

Potential NAD drawbacks to consider

While liposomal delivery has the potential to be more efficient than other methods, research has yet to confirm this claim. In fact, there is conflicting evidence on its effects.

How the liposomal NAD supplement will affect you also depends on the specific product. The authorities, such as the Food and Drug Administration, don’t regulate supplements as closely as medications, so some available products may be low quality.

Liposomal formulations are complex and expensive to make, so some manufacturers tend to cut costs and opt for the most basic form of liposomes, which are delicate and break down faster. As a result, the active compound may be released prematurely, or liposomes may end up in other locations, which could cause health problems. Subpar products can also contain impurities or even harmful ingredients.

If you decide to use liposomal NAD supplements, buy them from a reputable company that’s transparent about its products, ingredients, and production processes.

Source: Pilan Filmes

Bonus read: Check out our other articles on supplements and other biohacking practices:

• Adaptogens and nootropics

• Biohacking diet

• Sleep tracking

• Red light therapy benefits for hair

Potential health benefits of liposomal NAD supplements 

Research on liposomal NAD and other NAD supplements is still in its early stages. Existing studies mainly used animal models and small human samples. Still, the evidence thus far is promising and will likely prompt further investigation. Check out the potential benefits of NAD in the following table:

| Potential benefit             | How NAD supplementation contributes                                                                                                                                                                                        |
| ----------------------------- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- |
| Slower aging                  | It was found that levels of NAD decrease significantly as we age and that they contribute to aging. Increasing NAD levels may have a wide range of benefits for the body, such as boosting muscle energy and repair.       |
| Treatment of age-related conditions | NAD supplementation may improve the symptoms of various cardiovascular, neurodegenerative, and metabolic diseases and help the skin regenerate.                                                                           |
| Nervous system protection     | NAD boosters may also have neuroprotective effects, shielding nerve cells from damage and degeneration and potentially preventing diseases like Alzheimer’s and Parkinson’s.                                                |
| Inflammation regulation       | NAD plays a vital role in inflammatory responses, which happen as the immune system deals with various external and internal threats. NAD supplements may prevent or delay the onset of chronic conditions such as rheumatoid arthritis and heart disease. |
| Metabolic health support      | Some studies also suggest that NAD boosters improve some factors of metabolic health, such as blood pressure, aid in weight management, and reduce the likelihood of metabolic syndrome

Healthy individuals also use NAD supplements for their nootropic effects, but the actual benefits haven’t been confirmed by research yet.

Potential side effects of liposomal NAD supplements

Existing studies agree that NAD boosters are generally well-tolerated by humans. Higher doses caused few and relatively mild side effects, such as:

• Nausea

• Headache

• Rash

• Fatigue 

Severe negative reactions included liver damage and increased inflammation. 

Although there’s evidence of NAD supplements’ safety, you should still be cautious. Science is yet to discover their long-term effects, interactions with other substances, and optimal dosages. Product quality variations and individual differences could also contribute to the development of adverse reactions.

Should you use liposomal NAD?

Liposomal NAD supplements can benefit some people, especially those of mid or older age. Still, you need to take several precautions to reduce the likelihood of negative reactions. 

Before regular consumption, consult a healthcare professional. They can determine whether NAD supplementation is right for you and advise you on the best course of action. They may recommend a product or advise on other ways to increase your NAD levels, such as through your diet (caloric restriction) or regular exercise.

Understanding your body’s specificities and needs is an essential step in making any decision about diet, supplementation, and overall lifestyle choices. Genetic testing, for example, can help you learn about your genetic makeup and how it influences different aspects of your life and health, including the potential reaction to NAD boosters.

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Featured image source: Jonathan Borba