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4.8/5
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Join Nucleus
Friends of the Hoeflingers get $100 off.
$399
$499
+ Annual membership ($3/mo, billed annually)
At-home whole-genome DNA test uncovers genetic risks for 2000+ conditions with one swab.
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30x whole-genome sequencing
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Easy-to-read reports
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Custom plan of next steps
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Option for 1:1 genetic counseling
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Cancel membership anytime
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HSA/FSA eligible
Pay with any eligible card.
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Free shipping
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Results in 4-6 weeks
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CLIA-certified
trusted by experts at
Verified 5-star reviews
What Dr. Hoeflinger says
We test your genetic risk for 2000+ conditions to help you understand and reduce your risks for…
cardiology
Heart disease
Hypertension, coronary artery disease, and more
immunology
Cancer
Breast, prostate, colorectal, and more cancers
mindfulness
Mental health
Anxiety, bipolar, schizophrenia, and more
neurology
Cognitive health
Alzheimer's, Parkinson's, migraines, and more
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Focus & energy
ADHD, insomnia, asthma, chronic pain, and more
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Vision
Age-related macular degeneration, and more
gastroenterology
Food & digestion
Type 2 diabetes, celiac disease, alcoholism, and more
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And hundreds more
Rare genetic diseases, traits, and more
Test from the comfort of home.
1
Order your kit
Free shipping to your home.
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Collect your sample
Swab your cheek to collect your sample.
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Results in 4-6 weeks
Get clarity on your health risks.
30x
Sequencing depth
Why test your whole genome?
You should do Nucleus if:
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You want to live as long as possible
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You want to understand your health risks
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You have a family history of disease
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You have undiagnosed symptoms
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You weren't satisfied with other tests
When people use Nucleus
Results anyone can understand
Explore choices, make a plan, and improve your health with easy-to-read reports.
What's in the box
In the box
Included with your purchase
FAQ
What is Nucleus?
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Nucleus offers a complete family planning experience, from preconception genetic testing to advanced embryo analysis and IVF care. We help you understand your own genetics and your future child’s, so you can plan with more clarity and confidence.
Where should I start?
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It depends where you are in your journey.
If you’re just starting to think about having a child, Nucleus Preview is a simple first step. It helps you understand your own health and what you might pass on, before conception.
If you’re already going through IVF, Nucleus Embryo gives you a clearer picture of your embryos so you can choose with more confidence. It’s easily integrated into any existing IVF care.
If you’re planning to do IVF and want a more supported experience, Nucleus IVF+ brings everything together in one seamless path, from clinic matching through to advanced genetic analysis and pregnancy.
Not sure where to begin? We’re always here to help you figure it out. Reach out to our concierge team anytime - concierge@mynucleus.com.
How should I use this information?
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Our genetic insights are here to give you more information, not to tell you what to do.
With Preview, many people use their results to plan ahead for children, understand their own potential health risks, and have more informed conversations with their doctor. Some go on to conceive naturally, just with more clarity, while others explore IVF if it feels right for them.
For Embryo, the insights are used by the parents to compare embryos and make their own decisions during IVF.
How do I get my results?
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Your results are delivered in your Nucleus account through clear, easy-to-understand reports.
You can access them anytime, and if you have questions, a genetic counselor is available to talk everything through with you.
How accurate are Nucleus’ results?
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Nucleus’ whole-genome DNA analysis is more than 99.9% accurate. As a clinical-grade test, we’re held to the highest standards to ensure the quality of your DNA analysis.
That said, it’s important to understand how different types of genetic results work.
Some conditions are caused by a single gene. In those cases, results can be highly definitive, showing whether a specific variant is present or not.
But most health conditions and traits, like cancer risk, heart disease, or height, are influenced by many genes working together. These results are probabilistic, not certain. They reflect likelihood, not guarantees.
That’s not a limitation of Nucleus — it’s how genetics works. Environment, lifestyle, and chance also play a role. Nucleus helps you understand risk and possibilities, so you can make more informed decisions.
Do I need to be doing IVF to do Nucleus?
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Not at all. Nucleus is designed for many different paths to parenthood.
If you’re still early in your journey, we recommend starting with Nucleus Preview. It gives couples (and individuals) insight into what could be passed on to your future child, so you have more information, whatever path you take.
How much does Nucleus cost?
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In the U.S., Nucleus’ offerings are priced as follows:
Nucleus Preview is $949 including two DNA kits + $39/year/person membership
Nucleus Embryo is $9,999
Nucleus IVF+ is as little as $9,999/month for four months, depending on clinic location.
How long does Nucleus take?
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Timings vary depending on where you are in your journey and which Nucleus offering you choose.
Preview
Once you place your order, we’ll send everything you need, including your test kits. Collecting your sample is simple with a quick cheek swab. After you send it back using the prepaid label, your results are typically ready within 4-6 weeks.Embryo
Timelines depend on your clinic and lab. Once we receive your embryo data, your analysis is usually ready within 1–2 weeks.IVF+
IVF+ follows the natural timeline of IVF. Because it’s built around your care, timing will depend on your individual treatment plan but we’ll guide you every step of the way.
Will someone help me understand my results?
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Yes. You’ll have access to genetic counselors who can walk you through your results and help you understand what they mean for you.
If you’re doing Nucleus Embryo or IVF+, your Nucleus results will also be shared with your existing IVF care team, including your physician, so you feel supported from every angle.
Still have questions?
Get answers from an expert.
Member Reviews
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4.8/5
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Irina
The test picked up my rare genetic condition—this is an incredible test! It’s actually my fourth DNA test, and the only one that identified it.
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Jeffrey
The process couldn’t have been more straightforward. No blood draws…no Dr. visits…just a quick swab of my cheeks.
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Yasir
Just found that my genetic risk of diabetes is higher than 99.9% who share the same ancestry as me. It is one of the most insightful products i've ever used.
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Alexis
As the father of two girls (and son of a mom who had breast cancer), I'm grateful to know about my disease risks so we can plan better as a family.
