12
11
10
9
8
7
6
5
4
3
2
1
0
55.3% risk
reduction
reduction
0
0
2
5
10
Random
embryo
embryo
# of embryos to select from
Labs
Genetic Optimization Hub
Genetic Optimization Hub
A public hub for companies, labs and researchers to open-weight and share the accuracy of their models.
A public hub for companies, labs and researchers to open-weight and share the accuracy of their models.
Featured models
Our flagship and open-weighted prediction model. Trained and validated on millions of people across diverse ancestries.
Our flagship and open-weighted prediction model. Trained and validated on millions of people across diverse ancestries.
Thompson
2024
Genomics plc paper presented a flagship set of PRS developed and validated across multiple biobanks.
Thompson
2024
Genomics plc paper presented a flagship set of PRS developed and validated across multiple biobanks.
Mars
2022
Researchers at the University of Helsinki and the Broad validated PRS in the FinnGen biobank, showing large improvements over previous work.
Mars
2022
Researchers at the University of Helsinki and the Broad validated PRS in the FinnGen biobank, showing large improvements over previous work.
Benchmarks
Liability R² by disease
Origin
Thompson
Mars
Liability R2
0.3
0.2
0.1
0
Alzheimer's disease
Breast cancer
CAD
Endometriosis
Hypertension
Prostate cancer
Rheumatoid arthritis
Type 1 diabetes
Type 2 diabetes
Liability R² by Disease and Ancestry
African
Admixed American
East Asian
South Asian
Liability R2
0.3
0.2
0.1
0
Breast cancer
CAD
Endometriosis
Hypertension
Prostate cancer
Rheumatoid arthritis
Type 2 diabetes
See risk reductions for
Alzheimers risk can be reduced by up to 55.3% when selecting from 5 embryos.
Estimated risk (%)
Request Origin model weights
All researchers are invited to evaluate, build upon, and get access to Origin.
Request Origin model weights
All researchers are invited to evaluate, build upon, and get access to Origin.
References
Mars N, Lindbohm JV, Della Briotta Parolo P, et al. Systematic comparison of family history and polygenic risk across 24 common diseases. Am J Hum Genet. 2022 Dec 1;109(12):2152-2162. doi: 10.1016/j.ajhg.2022.10.009. Epub 2022 Nov 7. PMID: 36347255.
Thompson DJ, Wells D, Selzam S, et al. A systematic evaluation of the performance and properties of the UK Biobank Polygenic Risk Score (PRS) Release. PLoS One. 2024 Sep 18;19(9):e0307270. doi: 10.1371/journal.pone.0307270. PMID: 39292644.
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