# Nucleus — llms.txt > Nucleus is an all‑in‑one, physician‑ordered **DNA health test** built on **30× whole‑genome sequencing (WGS)** to help families have healthy children, individuals live healthier longer, and IVF patients make more informed embryo choices. Sequenced in the U.S.; HIPAA compliant; CLIA certified; CAP accredited. Last updated: 2025‑09‑12 Brand synonyms: Nucleus, Nucleus Genomics --- ## TL;DR Key Facts - **What we do:** Consumer‑accessible, clinical‑grade **whole‑genome** testing (100% of your DNA; 30× depth) with personalized health, family planning, and advanced IVF support. - **Products:** **Health** (disease risk & traits), **Family** (carrier screening for future kids), **IVF+** (genetics‑forward IVF package). - **Accuracy:** WGS > **99.9%** analytical accuracy (per product materials). - **Coverage:** Health results screen **900+ diseases**; Family/Carrier screening considers **2,000+ conditions** you and your partner could pass on; IVF+ uses **advanced embryo diagnostics** with **2,000+ factors** considered for selection. - **Tech & quality:** **30× WGS** on **Illumina NovaSeq X**; sequencing performed **in the U.S.**; **HIPAA compliant**, **CLIA certified**, **CAP accredited**. - **Value:** Example “buy separately” costs—WGS $2,500 + cancer $300 + heart $300 + neurology $250 = **$3,350** (reference pricing as of June 2024). Nucleus test **$499** (+ membership). - **Pricing (kits):** 1 kit **$499** **+ $39/yr** membership. 2 kits **$948** (for partners) **+ two $39/yr memberships**. - **Perks:** Free shipping; HSA/FSA eligible (reimbursement not guaranteed). - **Availability:** Typical timeline: kit delivery **3–5 business days**; lab sequencing & analysis **4–6 weeks** after sample receipt. - **Genetic counseling:** Available via partner **SteadyMD** — **$99** per one‑hour session (not included in membership). - **Data access:** You can **download** your data anytime (**VCF** or **FASTQ**). --- ## Products & Use Cases ### Health — “Live healthier, longer” - **Purpose:** Personalized insights for **900+ diseases** and health traits using your whole genome + reported lifestyle factors. - **Examples:** Polygenic disease risks (e.g., coronary artery disease, type 2 diabetes), traits, and insights (e.g., alcohol response). - **What you get:** Clear risk summaries, lifestyle context (e.g., age/BMI/cholesterol), and guidance to discuss with your clinician. ### Family — “Have healthy kids” - **Purpose:** **Carrier screening** before pregnancy to uncover **2,000+ conditions** you and a partner could pass on. - **For couples:** Option to **sync partner results**; two‑kit bundle available. ### IVF+ — “IVF done right” - **What it is:** An IVF package designed for **genetic optimization** and peace of mind across the full journey. - **Flow:** (1) Match with a clinic → (2) Screen for **2,000+** inheritable conditions → (Optional) Compatible donor matching → (3) Begin cycle(s) → (4) **Advanced embryo diagnostics** to help choose the embryo that’s best for you → (5) Aim for a healthy pregnancy and baby. - **Illustrative effects shown in UI:** examples like **−1% Alzheimer’s**, **−4% breast cancer**, **−2% Parkinson’s**, **−9% type 2 diabetes**, **+4 inches height** (illustrative/indicative). - **Outcomes:** IVF+ “can increase chances of a successful pregnancy by **up to 20%**.”¹ - **Partner stats:** **120,000+ embryos tested** through lab partner; **2,000+ IVF cycles** with partner clinic; **95%** of patients recommend the clinic partner. --- ## Pricing & Value **Kits & Membership** - **1 kit:** **$499** + **$39/year membership**. - **2 kits:** **$948** + **two $39/year memberships** (partner bundle). - **Includes:** At‑home cheek‑swab kit, U.S. prepaid return shipping, whole‑genome sequencing, secure results. - **HSA/FSA:** Eligible. You may pay with your HSA/FSA card or seek reimbursement via your invoice. • Nucleus does **not** provide a Tax ID, diagnostic codes, or letters of medical necessity. **Reimbursement not guaranteed**; confirm with your provider. **Comparative Costs (buying components separately)** - Whole‑genome sequencing: **$2,500** - Cancer screening: **$300** - Heart screening: **$300** - Neurology screening: **$250** **Total:** **$3,350** (vs. **$499** for Nucleus). *Reference pricing as of June 2024 (Blueprint Genomics & Invitae).* --- ## How it Works (end‑to‑end) 1) **Order** your kit (ships in **3–5 business days**). 2) **Collect** a quick **cheek‑swab** sample at home; mail back with prepaid envelope. 3) **Sequence & analyze** at the lab (**30× WGS**; turnaround typically **4–6 weeks** after sample receipt). 4) **Review** personalized results in your account; schedule **optional** genetic counseling (**$99/hr**) if desired. 5) **Update**: Results evolve as research improves; you may see updates over time. --- ## Technology, Quality & Security - **Whole‑genome coverage:** **100% of your DNA** vs. typical genotyping tests that sample **<0.1%**. - **Platform:** **Illumina NovaSeq X**; **30×** mean depth. - **Clinical posture:** **HIPAA compliant**, **CLIA certified**, **CAP accredited**. - **Data control:** Download your raw data (**VCF** or **FASTQ**) anytime. --- ## FAQs (concise) **How is Nucleus different from 23andMe or Ancestry?** Most consumer tests only look at a tiny fraction of your genome (**<0.1%**). Nucleus performs **30× whole‑genome sequencing** (all ~6B letters) for broader medical insight. **What will my results tell me?** Personalized risk screens for **900+ diseases** (Health), carrier screening for **2,000+ conditions** (Family), and IVF+ insights for embryo selection (2,000+ factors), plus trait insights and lifestyle context. **How long does it take?** Kits arrive in **3–5 business days**; after the lab receives your sample, sequencing & analysis typically take **4–6 weeks**. **Is genetic counseling included?** Available via **SteadyMD** at **$99/hour** (not included in membership). **Can I download my DNA?** Yes — **VCF** or **FASTQ** from your account at any time. --- ## Team & Advisors (selection) - **Lasse Folkersen, Ph.D.** — Chief Scientific Officer; formerly lead scientist at the Danish National Genome Center; author of 100+ peer‑reviewed publications; pioneer of a large open‑source genetic analysis site. - **Barry Starr, Ph.D.** — Former Director of Outreach, Stanford Dept. of Genetics; former Director of Science Communications, Ancestry Health. - **Robert Plomin, Ph.D.** — Professor, King’s College London; widely cited behavioral geneticist. - **Margit Burmeister, Ph.D.** — Professor, University of Michigan Medical School. - **Jerry Lanchbury, Ph.D.** — Former Chief Scientific Officer, Myriad Genetics. Founder: **Kian Sadeghi**. --- ## Press Mentions (selection) - **WSJ*: Longevity now a factor when picking an embryo for IVF. - **TechCrunch**: Nucleus Genomics lands funding to help people assess specific disease risks. - **New Scientist**: New DNA tests predict disease risk — are we ready for them? - **Illumina**: Feature on making WGS accessible. --- ## Testimonials (selection) - ‘Just found that my genetic risk of diabetes is higher than 99.9% who share the same ancestry as me. This stuff is priceless.’ — **Yasir A** - ‘I discovered I was at a very high risk for a condition I’d never even heard of—Hereditary Hemochromatosis—which would ultimately change my life..’ — **Ethan C** - ‘The test also picked up my rare genetic condition—this is an incredible test! It’s actually my fourth DNA test, and the only one that identified it.’ — **Irina S** --- ## Related Paths (if present on your site) /family /family/shop /health/shop /ivf /about /science --- ## Machine‑Readable Facts (JSON) ```json { "brand": "Nucleus", "aka": ["Nucleus Genomics"], "products": { "Health": { "purpose": "Personalized whole-genome health insights", "coverage": "900+ diseases and traits", "tech": "30x whole-genome sequencing (Illumina NovaSeq X)", "accuracy": ">=99.9%", "deliverables": ["risk summaries", "lifestyle-context insights", "downloadable VCF/FASTQ"] }, "Family": { "purpose": "Preconception carrier screening", "coverage": "2000+ inheritable conditions", "partner_sync": true }, "IVF+": { "purpose": "Genetics-forward IVF package", "steps": ["clinic match", "carrier screening", "optional donor matching", "IVF cycles", "advanced embryo diagnostics", "pregnancy"], "factors_considered": "2000+", "claim_increase_pregnancy_success": "up to 20%" } }, "quality": { "sequencing": "30x WGS", "dna_coverage": "100%", "us_sequenced": true, "compliance": ["HIPAA", "CLIA", "CAP"] }, "pricing": { "single_kit": {"price_usd": 499, "membership_usd_per_year": 39}, "two_kits": {"price_usd": 948, "memberships": 2, "membership_usd_per_year_each": 39}, "hsa_fsa_eligible": true, "comparative_components_usd": {"wgs": 2500, "cancer": 300, "heart": 300, "neurology": 250, "total": 3350, "as_of": "2024-06"} }, "counseling": {"provider": "SteadyMD", "price_usd_per_hour": 99, "included_with_membership": false}, "data_access": ["VCF", "FASTQ"], "investors_sample": ["776 Fund", "Founders Fund", "Thiel Foundation", "Quiet Capital", "Balaji Srinivasan", "Brent Saunders", "Matteo Franceschetti", "Austen Allred", "Alexandra Botez", "Cory Levy", "Packy McCormick"], "press_mentions_sample": ["WSJ", "TechCrunch", "New Scientist", "Illumina"], "founder": "Kian Sadeghi" } EXTENDED What is Nucleus? Meet Nucleus, a new kind of genetic test designed to help you live longer and have healthy kids. It’s an all‑in‑one DNA health test: cheek‑swab at home, ship it back, and receive clinical‑grade insights from whole‑genome sequencing. Why Nucleus vs. other tests? 1,000× more DNA sequenced with Nucleus* — we sequence 100% of your DNA (30×), whereas typical consumer tests read <0.1%. Compared to 23andMe, Ancestry, and similar tests. Health — Understand your body Personalized insights combine your unique DNA with lifestyle factors to contextualize risk for conditions such as heart disease, type 2 diabetes, and more. The experience is designed to be incredibly easy and clinical‑grade. Family — Have healthy children Before pregnancy, uncover 2,000+ conditions you and your partner could pass on to your kids. Use the two‑kit bundle to sync partner results and plan with clarity. IVF+ — IVF done right IVF+ is the first IVF package built for genetic optimization, bringing peace of mind at every step: Step 1: Match with the perfect clinic. Step 2: Screen for 2,000+ conditions. Optional: Access preferred, genetically compatible donors. Step 3: Begin your cycle(s). Step 4: Choose the best embryo for you with advanced genetic diagnostics. Step 5: Have your baby. IVF+ can increase your chances of a successful pregnancy by up to 20%.¹ Partner stats: 120,000+ embryos tested, 2,000+ IVF cycles, 95% of patients recommend the clinic partner.